Serum ceruloplasmin concentrations in rats with primary and transplanted sarcomas induced by nickel subsulfide

Journal Article · Mon Jan 01 04:00:00 EST 1979 · Ann. Clin. Lab. Sci.; (United States)

OSTI ID:6783495

Sunderman, Jr, F W; Trudeau, Jr, E A; Horak, E; Mitchell, J M; Allpass, P R

Ceruloplasmin (CPN) concentrations were measured by p-phenylenediamine oxidase assay in serums from (a) 30 control Ficher rats; (b) 5 rats with primary sarcomas induced by i.m. injection of nickel subsulfide (..cap alpha..Ni/sub 3/S/sub 2/), and (c) 12 rats at intervals up to six weeks after s.c. transplantation of four ..cap alpha..Ni/sub 3/S/sub 2/-induced sarcomas. Serum CPN concentrations were not significantly increased in rats with primary sarcomas (mean = 0.38 g per liter) (S.D. +- 0.05), versus 0.35 g per liter (S.D. +- 0.04) in controls. In contrast, serum CPN concentratins were increased witin 11 to 21 days in all rats with transplanted sarcomas. Maximum concentrations of serum CPN occurred at 31 to 34 days after tumor transplantation, (mean = 0.56 +- 0.05 g per liter), equivalent to 1.6 +- 0.2 times the initial CPN concentrations in serums obtained prior to treatment (P <0.001). The development of hyperceruloplasminemia in rats with transplanted sarcomas and not in rats with primary sarcomas is attributed to greatly enhanced growth-rates of the transplanted neoplasms.

• Research Organization: Univ. of Connecticut, Farmington
• DOE Contract Number: EY-76-S-02-3140
• OSTI ID: 6783495
• Journal Information: Ann. Clin. Lab. Sci.; (United States), Journal Name: Ann. Clin. Lab. Sci.; (United States) Vol. 9:1; ISSN ACLSC
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
560305* -- Chemicals Metabolism &amp; Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOASSAY
BIOLOGICAL EFFECTS
BLOOD CHEMISTRY
BLOOD SERUM
CERULOPLASMIN
CHALCOGENIDES
COMPLEXES
COPPER
COPPER COMPLEXES
DATA
DISEASES
ELEMENTS
ENZYMES
EXPERIMENTAL DATA
EXPERIMENTAL NEOPLASMS
GLOBULINS
GLOBULINS-ALPHA
GROWTH
INFORMATION
INJECTION
INTAKE
INTRAMUSCULAR INJECTION
MAMMALS
METALS
NEOPLASMS
NICKEL COMPOUNDS
NICKEL SULFIDES
NUMERICAL DATA
ORGANIC COMPOUNDS
PROTEINS
QUANTITY RATIO
RATS
RODENTS
SARCOMAS
SULFIDES
SULFUR COMPOUNDS
TIME DEPENDENCE
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENT COMPOUNDS
TRANSITION ELEMENTS
TRANSPLANTS
VERTEBRATES