Effects of manganese on carcinogenicity and metabolism of nickel subsulfide. [Rats]

Journal Article · Sat May 01 04:00:00 EDT 1976 · Cancer Res.; (United States)

OSTI ID:7313339

Sunderman, Jr, F W; Kasprzak, K S; Lau, T J; Minghetti, P P; Maenza, R M; Becker, N; Onkelinx, C; Goldblatt, P J

Nickel subsulfide, Ni/sub 3/S/sub 2/, alone or combined with manganese or chromium dusts, was administered i.m. to Fischer rats to study the effects of the metals upon Ni/sub 3/S/sub 2/ induction of sarcomas at the injection site. The incidence of sarcomas within 2 years after injection of Ni/sub 3/S/sub 2/ (1.2 mg) plus manganese (1.0 mg) was 7%, versus 77% in rats that received only Ni/sub 3/S/sub 2/ (1.2 mg), and 80% in rats that received Ni/sub 3/S/sub 2/ (1.2 mg) plus chromium (1.0 mg) (rho less than 0.005). No local sarcomas occurred in rats that received the injection vehicle, or in rats that received manganese or chromium without Ni/sub 3/S/sub 2/. Admixture of manganese diminished the solubility of /sup 63/Ni/sub 3/S/sub 2/ in rat serum, serum ultrafiltrate, or water, in vitro. Admixture of manganese with /sup 63/Ni/sub 3/S/sub 2/ does not affect the mobilization or excretion of /sup 63/Ni in vivo, nor did it alter the acute pathological reactions to Ni/sub 3/S/sub 2/. /sup 63/Ni concentrations in ultrafiltrates of supernatant fractions of homogenates of injection sites averaged 2.8 (S. D. +-0.7) ng/ml at 5 to 6 months after injection of /sup 63/Ni/sub 3/S/sub 2/ (1.2 mg) plus manganese (1.0 mg), versus 5.4 +- 2.0 ng/ml after injection of only /sup 63/Ni/sub 3/S/sub 2/ (1.2 mg) (rho less than 0.02). This study demonstrates that admixture of manganese dust and Ni/sub 3/S/sub 2/ inhibits Ni/sub 3/S/sub 2/ tumorigenesis in rats, and reveals that manganese dust affects the subcellular distribution of /sup 63/Ni derived from /sup 63/Ni/sub 3/S/sub 2/, without influencing /sup 63/Ni kinetics as estimated by compartmental analysis.

• Research Organization: Univ. of Connecticut, Farmington
• OSTI ID: 7313339
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 36; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CARCINOGENESIS
CHALCOGENIDES
CHROMIUM
DISEASES
DUSTS
ELEMENTS
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MANGANESE
METABOLISM
METALS
NEOPLASMS
NICKEL 63
NICKEL COMPOUNDS
NICKEL ISOTOPES
NICKEL SULFIDES
NUCLEI
PATHOGENESIS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
SARCOMAS
SULFIDES
SULFUR COMPOUNDS
TRANSITION ELEMENT COMPOUNDS
TRANSITION ELEMENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES