Mechanisms of dissolution of nickel subsulfide in rat serum

Journal Article · Sat Jan 01 04:00:00 EST 1977 · Res. Commun. Chem. Pathol. Pharmacol.; (United States)

OSTI ID:7304793

Kasprzak, K S; Sunderman, Jr, F W

To elucidate the initial steps of carcinogenesis by nickel subsulfide, the mechanisms of dissolution of ..cap alpha..-Ni/sub 3/S/sub 2/ were studied by incubating ..cap alpha..-Ni/sub 3/S/sub 2/ dust in (a) water, (b) rat serum, and (c) rat serum ultrafiltrate. The sediments that remained following incubationn of ..cap alpha..-Ni/sub 3/S/sub 2/ in the 3 media for 2 weeks were examined by x-ray diffractometry. The rates of solubilization of /sup 63/Ni from ..cap alpha..-/sup 63/Ni/sub 3/S/sub 2/ during incubation in the 3 media were measured by liquid scintillation counting. These studies showed that solubilization of Ni(II) from ..cap alpha..-Ni/sub 3/S/sub 2/ in rat serum requires the presence of O/sub 2/ and involves three reactions: (I) 2..cap alpha..-Ni/sub 3/S/sub 2/ + O/sup 2/ + 2H/sub 2/O ..-->.. 4 ..beta..-NiS + 2Ni (OH)/sub 2/; (II) ..beta..-NiS + 2O/sub 2/ ..-->.. Ni/sup 2 +/ + SO/sub 4//sup 2 -/; and (III) Ni/sup 2 +/ and Ni(OH)/sub 2/ + serum ligands (albumin and amino acids) ..-->.. soluble Ni(II)-complexes. The rate of solubilization of /sup 63/Ni from ..cap alpha..-/sup 63/Ni/sub 3/S/sub 2/ was initially more rapid in rat serum than in serum ultrafiltrate and much more rapid than in water. After 2 days of incubation, the rates of dissolution of ..cap alpha..-/sup 63/Ni/sub 3/S/sub 2/ in the 3 media became progressively retarded, probably owing to deposition of insoluble surface coatings of ..beta..-/sup 63/NiS and /sup 63/Ni(OH)/sub 2/ on the ..cap alpha..-/sup 63/Ni/sub 3/S/sub 2/ particles.

• Research Organization: Poznan Polytechnical Univ., Poland
• OSTI ID: 7304793
• Journal Information: Res. Commun. Chem. Pathol. Pharmacol.; (United States), Journal Name: Res. Commun. Chem. Pathol. Pharmacol.; (United States) Vol. 16:1; ISSN RCOCB
• Country of Publication: United States
• Language: English

Related Subjects

550201 -- Biochemistry-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD SERUM
CARCINOGENESIS
CHALCOGENIDES
CHEMICAL REACTION KINETICS
CRYOGENIC FLUIDS
ELEMENTS
EVEN-ODD NUCLEI
FLUIDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
KINETICS
LABELLED COMPOUNDS
MAMMALS
NICKEL 63
NICKEL COMPOUNDS
NICKEL ISOTOPES
NICKEL SULFIDES
NONMETALS
NUCLEI
OXYGEN
PATHOGENESIS
RADIOISOTOPES
RATS
REACTION KINETICS
RODENTS
SOLUBILITY
SULFIDES
SULFUR COMPOUNDS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES