Dissolution half-times of nickel compounds in water, rat serum, and renal cytosol

Journal Article · Fri Jan 01 04:00:00 EST 1982 · J. Inorg. Biochem.; (United States)

DOI:https://doi.org/10.1016/S0162-0134(00)80227-5· OSTI ID:6169408

Kuehn, K; Sunderman, Jr, F W

Seventeen nickel compounds were incubated in water, rat serum, and rat renal cytosol for 72 hr at 37/sup 0/C. Concentrations of dissolved nickel were analyzed by electrothermal atomic absorption spectrophotometry, and dissolution half-times (T50) were computed by the Weibull equation. Eleven of the nickel compounds (Ni, ..beta..NiS, amorphous NiS, ..cap alpha..Ni/sub 3/S/sub 2/, NiSe, Ni/sub 3/Se/sub 2/, NiTe, NiAs, Ni/sub 11/As/sub 8/, Ni/sub 5/As/sub 2/, and NiFeS/sub 4/) dissolved more rapidly in serum or cytosol than in water. Four of the compounds (NiO, NiSb, NiFe alloy, and NiTiO/sub 3/) had no detectable dissolution in any of the media (i.e., T50 > 11 yr). One compound (NiAsS) had approximately equal T50 values in the three media; the T50 value of one compound (NiS/sub 2/) could not be determined in serum or cytosol owing to precipitation. T50 values of 34 and 21 days for dissolution of ..cap alpha..Ni/sub 3/S/sub 2/ in serum and cytosol, respectively, agree closely with the excretion half-time of 24 days derived from previously reported data for excretion of /sup 63/Ni in urine and feces of rats after intramuscular injection of ..cap alpha../sup 63/Ni/sub 3/S/sub 2/. These findings suggest that in vitro dissolution half-times of nickel compounds may be used to predict their in vivo excretion half-times, since the dissolution process is rate-limiting to their metabolism and excretion.

• Research Organization: Univ. of Connecticut School of Medicine, Farmington
• DOE Contract Number: AC02-76EV03140
• OSTI ID: 6169408
• Journal Information: J. Inorg. Biochem.; (United States), Journal Name: J. Inorg. Biochem.; (United States); ISSN JIBID
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL HALF-LIFE
BIOLOGICAL MATERIALS
BLOOD SERUM
BODY
BODY FLUIDS
CLEARANCE
COMPARATIVE EVALUATIONS
DISSOLUTION
EXCRETION
HYDROGEN COMPOUNDS
KIDNEYS
MAMMALS
MATERIALS
METABOLISM
NICKEL COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
RATS
RODENTS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
WATER