Association between erythrocytosis and renal cancers in rats following intrarenal injection of nickel compounds

Journal Article · Sun Jan 01 04:00:00 EST 1984 · Carcinogenesis (N.Y.); (United States)

DOI:https://doi.org/10.1093/carcin/5.11.1511· OSTI ID:6289856

Sunderman, Jr, F W; McCully, K S; Hopfer, S M

Seventeen nickel compounds were administered to Fischer-344 rats (N=270) by intrarenal injection (7 mg Ni/rat); the compounds included nickel sulfides, selenides, arsenides, oxide, antimonide, telluride, titanate, ferronickel alloy and metallic nickel dust. Erythrocytosis, as defined by peak hematocrit values that averaged >55% during 1-4 months post-injection, occurred in nine of 17 Ni-treated groups (NiS2, US NiS, NiS2, Ni4FeS4, NiSe, Ni3Se2, NiAsS, NiO, Ni dust). Renal cancers (N=23) developed within 2 years post-injection in nine of 17 Ni-treated groups (NiS2, US NiS, Ni3S2, Ni4FeS4, NiSe, Ni3Se2, NiAsS, NiAs, NiFe alloy). The renal cancers included eight fibrosarcomas, five mesangial cell sarcomas, two renal cell carcinomas, two carcinosarcomas, two leiomyosarcomas, two undifferentiated sarcomas, one rhabdomyosarcoma and one nephroblastoma. No erythrocytosis or renal cancers occurred in control rats (N=97) in three groups treated with the vehicles or metallic iron dust. Rank correlation (p < 0.0001) was observed between the incidences of erythrocytosis and renal cancers in the 17 Ni-treated groups. Rank correlation (p <0.001) was observed between the present incidences of renal cancers and the sarcoma incidences previously reported following intramuscular administration of the 17 nickel compounds to Fischer-344 rats (14 mg Ni/rat). The incidences of renal cancer were not correlated with (i) the mass-fractions of nickel in the 17 compounds, (ii) the dissolution half-times of the compounds in rat serum or renal cytosol, or (iii) the phagocytic indices of the compounds in rat peritoneal macrophages. 48 references, 2 figures, 4 tables.

• Research Organization: Univ. of Connecticut School of Medicine, Farmington
• OSTI ID: 6289856
• Journal Information: Carcinogenesis (N.Y.); (United States), Journal Name: Carcinogenesis (N.Y.); (United States) Vol. 5:11; ISSN CRNGD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism &amp; Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARCINOGEN SCREENING
CARCINOGENESIS
CARCINOMAS
DATA
DISEASES
ERYTHROCYTES
EXPERIMENTAL DATA
INFORMATION
KIDNEYS
MAMMALS
MATERIALS
NEOPLASMS
NICKEL COMPOUNDS
NUMERICAL DATA
ORGANS
PATHOGENESIS
RATS
RODENTS
SARCOMAS
SCREENING
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES