Induction of renal cancers in rats by intrarenal injection of nickel subsulfide

Journal Article · Mon Jan 01 04:00:00 EST 1979 · J. Environ. Pathol. Toxicol.; (United States)

OSTI ID:6336702

Sunderman, Jr, F W; Maenza, R M; Hopfer, S M; Mitchell, J M; Allpass, P R; Damjanov, I

The carcinogenicity of nickel subsulfide (..cap alpha..Ni/sub 3/S/sub 2/) was studied following intrarenal (i.r.) injection in rats. Within 100 weeks after i.r. injection of 5 mg of ..cap alpha..Ni/sub 3/S/sub 2/, renal cancers were found in 64% of Wistar-Lewis rats, 50% of NIH Black rats, 28% of Fischer rats and 0% of Long-Evans rats. These findings demonstrate significant differences in susceptibilities of the four rat strains to ..cap alpha..Ni/sub 3/S/sub 2/-induction of renal cancers. No renal cancers were found in male Fischer rats that received i.r. injection of ..cap alpha..Ni/sub 3/S/sub 2/-induction of renal cancers. No renal cancers were found in male Fischer rats that received i.r. injection of ..cap alpha..Ni/sub 3/S/sub 2/ in dosages of 0.6, 1.2 or 2.5 mg. In male Fischer rats that received i.r. injection of ..cap alpha..Ni/sub 3/S/sub 2/ in dosages of 5 or 10 mg, the incidences of renal cancers were 28% and 75%, respectively. These findings demonstrate a dose response relationship for ..cap alpha..Ni/sub 3/S/sub 2/-induction of renal cancers. In male Fischer rats that received i.r. injection of 10 mg of ..cap alpha..Ni/sub 3/S/sub 2/ combined with 6.9 mg of Mn dust, the incidence of renal cancers was 32%, which differed significantly from the corresponding incidences of 75% and 0% in rats that received i.r. injections of only ..cap alpha..Ni/sub 3/S/sub 2/ (10 mg) or Mn dust (6.9 mg). These findings demonstrate that ..cap alpha..Ni/sub 3/S/sub 2/-induction of renal cancers is inhibited by simultaneous administration of manganese dust. The 54 renal tumors that were found in this study were all malignant, and distant metastases were present in 69% of tumor-bearing rats. The histogenesis of ..cap alpha..Ni/sub 3/S/sub 2/-induced renal tumors from epithelial or mesenchymal progenitor cells could not be definitely established.

• Research Organization: Univ. of Connecticut, Farmington
• OSTI ID: 6336702
• Journal Information: J. Environ. Pathol. Toxicol.; (United States), Journal Name: J. Environ. Pathol. Toxicol.; (United States) Vol. 2; ISSN JEPTD
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL VARIABILITY
BODY
CARCINOGENESIS
CHALCOGENIDES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
INJECTION
INTAKE
KIDNEYS
MAMMALS
MANGANESE
METALS
NEOPLASMS
NICKEL COMPOUNDS
NICKEL SULFIDES
ORGANS
PATHOGENESIS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SENSITIVITY
SULFIDES
SULFUR COMPOUNDS
TIME DEPENDENCE
TRANSITION ELEMENT COMPOUNDS
TRANSITION ELEMENTS
TUMOR CELLS
VERTEBRATES