Effects of intrarenal injection of nickel subsulfide in rodents

Journal Article · Tue Jan 01 04:00:00 EST 1980 · Ann. Clin. Lab. Sci.; (United States)

OSTI ID:5841251

Hopfer, S M ^[1]; Sunderman, Jr, F W; Morse, E E; Fredrickson, T N

---

1. Univ. of Connecticut, Farmington

After intrarenal (i.r.) administration of 5 mg of nickel subsulfide (..cap alpha..Ni/sub 3/S/sub 2/) to Fischer rats, blood hematocrit became increased within one week and reached 76 +- 1 percent at eight weeks (p<0.001 versus mean hematocrit of 46 +- 1 percent in control rats). The ..cap alpha..Ni/sub 3/S/sub 2/-induced erythrocytosis was attended by intense stimulation of erythropoiesis, with reticulocytosis, increased /sup 59/Fe-uptake into erythrocytes and erythroid hyperplasia in bone marrow and spleen. The half-life of /sup 51/Cr-labeled erythrocytes from ..cap alpha..Ni/sub 3/S/sub 2/-treated rats was prolonged, consistent with increased proportion of circulating juvenile erythrocytes. Histological examination of rat kidneys after i.r. injection of ..cap alpha..Ni/sub 3/S/sub 2/ showed mile inflammation at one and two weeks. Dense black particles of ..cap alpha..Ni/sub 3/S/sub 2/ were visible in histological sections of rat kidneys for eight weeks. 5'-Nucleotidase activity in rat kidney microsomes was inhibited at one to seven days after i.r. injection of ..cap alpha..Ni/sub 3/S/sub 2/. Erythrocytosis did not occur in rats after (a) i.r. implantation of semi-permeable cellulose tubules containing ..cap alpha..Ni/sub 3/S/sub 2/, (b) repeated i.m. injections of ..cap alpha..Ni/sub 3/S/sub 2/, or (c) intrahepatic injection of ..cap alpha..Ni/sub 3/S/sub 2/ after partial hepatectomy. Erythrocytosis did not occur in male BALB/c mice or ground squirrels after i.r. injection of ..cap alpha..Ni/sub 3/S/sub 2/.

• DOE Contract Number: AC02-76EV03140
• OSTI ID: 5841251
• Journal Information: Ann. Clin. Lab. Sci.; (United States), Journal Name: Ann. Clin. Lab. Sci.; (United States) Vol. 10:1; ISSN ACLSC
• Country of Publication: United States
• Language: English

Related Subjects

550301 -- Cytology-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
560305* -- Chemicals Metabolism &amp; Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD FORMATION
BODY
BODY FLUIDS
BONE MARROW
CHALCOGENIDES
CHROMIUM 51
CHROMIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
ERYTHROCYTES
ERYTHROPOIESIS
EVEN-ODD NUCLEI
HEMATOPOIETIC SYSTEM
HISTOLOGY
INTERMEDIATE MASS NUCLEI
IRON 59
IRON ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
MAMMALS
MATERIALS
METALS
NICKEL
NICKEL COMPOUNDS
NICKEL SULFIDES
NUCLEI
ORGANS
RADIOISOTOPES
RATS
RODENTS
SENSITIVITY
SPLEEN
SULFIDES
SULFUR COMPOUNDS
TISSUES
TRACER TECHNIQUES
TRANSITION ELEMENT COMPOUNDS
TRANSITION ELEMENTS
VERTEBRATES