Effects of cobalt chloride, nickel chloride, and nickel subsulfide upon erythropoiesis in rats

Journal Article · · Ann. Clin. Lab. Sci.; (United States)

OSTI ID:5237024

Oskarsson, A; Reid, M C; Sunderman, Jr, F W

The erythropoietic effects of sustained intraperitoneal (i.p.) administration of CoCl/sub 2/ and NiCl/sub 2/ were compared with the effects of a single intrarenal (i.r.) injection of ..cap alpha..Ni/sub 3/S/sub 2/ in female Fischer-344 rats. Infusion of NiCl/sub 2/ by osmotic minipumps (0.85 mg Ni per day, i.p., for 24 days; total dose = 20 mg Ni per rat) did not alter the blood hematocrit or reticulocyte count during six weeks of observation. Under identical conditions, i.p. infusion of CoCl/sub 2/ (0.85 mg Co per day, i.p., for 24 days; total dose = 20 mg Co per rat) caused significant erythrocytosis (hematocrit at six weeks = 62 +/- 4 percent, P < 0.001 versus 50 +/- 3 percent in controls) and reticulocytosis (reticulocyte count at three weeks = 2.5 +/- 1.5 percent, P < 0.005 versus 0.8 +/- 0.7 percent in controls). Administration of ..cap alpha..Ni/sub 3/S/sub 2/ to rats as a single i.r. injection (7 mg Ni per rat) caused pronounced erythrocytosis (hematocrit at six weeks = 79 +/- 2 percent, P < 0.001 versus controls) and reticulocytosis (reticulocyte count at three weeks = 2.8 +/- 1.2 percent, P < 0.005 versus controls). This study demonstrates that i.p. infusion of Ni(II) is ineffective in stimulating erythropoiesis in rats, and that salient differences exist between the enhanced erythropoiesis that occurs in rats following i.p. infusion of Co(II) and that produced by i.r. injection of ..cap alpha..Ni/sub 3/S/sub 2/.

• Research Organization: Univ. of Connecticut, Farmington
• OSTI ID: 5237024
• Journal Information: Ann. Clin. Lab. Sci.; (United States), Journal Name: Ann. Clin. Lab. Sci.; (United States) Vol. 11:2; ISSN ACLSC
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism &amp; Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BLOOD FORMATION
CHALCOGENIDES
CHLORIDES
CHLORINE COMPOUNDS
COBALT CHLORIDES
COBALT COMPOUNDS
ERYTHROPOIESIS
HALIDES
HALOGEN COMPOUNDS
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
MAMMALS
NICKEL CHLORIDES
NICKEL COMPOUNDS
NICKEL SULFIDES
RATS
RODENTS
STIMULATION
SULFIDES
SULFUR COMPOUNDS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
WEIGHT