Erythropoietin-mediated erythrocytosis in rodents after intrarenal injection of nickel subsulfide

Journal Article · Fri Jan 01 04:00:00 EST 1982 · Yale J. Biol. Med.; (United States)

OSTI ID:6576947

Sunderman, Jr, F W; Hopfer, S M; Reid, M C; Shen, S K; Kevorkian, C B

Rats and guinea pigs developed pronounced erythrocytosis at one to four months after unilateral intrarenal (ir) injection of nickel subsulfide (Ni/sub 3/S/sub 2/). Hamsters and gerbils did not develop erythrocytosis after ir injection blood hematocrit. Erythrocytosis in rats was completely blocked by excision of the Ni/sub 3/S/sub 2/-injected kidney but was unaffected by excision of the non-injected kidney. Partial inhibition of Ni/sub 3/S/sub 2/-induced erythrocytosis in rats occurred after simultaneous ir injection of Mn, Cu, or Al dusts, benzo(a)pyrene, or subcutaneous (sc) infusion of sodium diethyldithiocarbamate. Erythrocytosis induced by ir injection of Ni/sub 3/S/sub 2/ was augmented by ir injection of Cr dust or intramuscular (im) administration of iron-dextran. Erythrocytosis occurred in rats after ir implantation of Ni/sub 3/S/sub 2/ within semi-permeable cellulose tubules, indicating that phagocytosis of Ni/sub 3/S/sub 2/ particles is unnecessary for erythropoietic stimulation. This study identifies several factors that influence erythropoietic stimulation by Ni/sub 3/S/sub 2/, and furnishes salient information concerning the pathogenesis of Ni/sub 3/S/sub 2/-induced erythrocytosis.

• Research Organization: Univ. of Connecticut School of Medicine, Farmington
• OSTI ID: 6576947
• Journal Information: Yale J. Biol. Med.; (United States), Journal Name: Yale J. Biol. Med.; (United States) Vol. 55; ISSN YJBMA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALUMINIUM
ANIMALS
AROMATICS
BENZOPYRENE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CHALCOGENIDES
CHELATING AGENTS
CHROMIUM
CONDENSED AROMATICS
COPPER
DAYS LIVING RADIOISOTOPES
DEDTC
DUSTS
ELEMENTS
ERYTHROCYTES
ERYTHROPOIETIN
EVEN-ODD NUCLEI
GERBILS
GUINEA PIGS
HAMSTERS
HEMATOLOGY
HYDROCARBONS
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
IRON 59
IRON ISOTOPES
ISOTOPES
KIDNEYS
MAMMALS
MANGANESE
MATERIALS
MEDICINE
METALS
NICKEL COMPOUNDS
NICKEL SULFIDES
NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIOISOTOPES
RATS
RODENTS
SPLEEN
SPLENECTOMY
SULFIDES
SULFUR COMPOUNDS
SURGERY
TRANSITION ELEMENT COMPOUNDS
TRANSITION ELEMENTS
UPTAKE
VERTEBRATES