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Glucose transport and utilization in the human brain: model using carbon-11 methylglucose and positron emission tomography

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:6782260
; ; ; ;

3-0-(11C)-Methyl-D-glucose (CMG) is specifically suited for measuring carrier facilitated glucose (G) transport; it enters the free G pool in tissue from where it is not utilized for metabolism in contrast to G, but is transported back into circulation. The ratio of carrier affinity for G and CMG was reported to be 1.11. By simultaneously measuring CMG concentration in plasma and in cerebral cortex in vivo with positron tomography at 1-min intervals for 40 min, two time-activity curves are obtained, as reported previously, which together with the G concentration in plasma yield the in vivo rate constants of G transport across the blood-brain barrier and the rate of G inflow; a repeat measurement at a different G concentration in plasma gives the in vivo Michaelis-Menten constant KM and the maximal rate of transport VMAX. The present paper summarizes and extends this approach to analyzing the free G pool in tissue, the rate of G return to circulation, and the rate of G exit into metabolism with its corresponding rate constants. The data from six volunteers agreed with results reported for the individual biochemical parameters in primate brains.

Research Organization:
Institute of Medicine, Nuclear Research Center, Juelich, Germany, F.R.
OSTI ID:
6782260
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 12; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD-BRAIN BARRIER
BODY
BRAIN
CARBOHYDRATES
CARBON 11
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
GLUCOSE
HEXOSES
ISOTOPES
LIGHT NUCLEI
MAMMALS
MAN
MATHEMATICAL MODELS
MEMBRANE TRANSPORT
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANS
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
RADIOISOTOPES
SACCHARIDES
TOMOGRAPHY
VERTEBRATES