Measurement of blood-brain hexose transport with dynamic PET: comparison of (/sup 18/F)2-fluoro-2-deoxyglucose and (/sup 11/C)O-methylglucose

Journal Article · Wed Feb 01 04:00:00 EST 1989 · J. Cereb. Blood Flow Metab.; (United States)

DOI:https://doi.org/10.1038/jcbfm.1989.14· OSTI ID:6499660

Herholz, K; Wienhard, K; Pietrzyk, U; Pawlik, G; Heiss, W D

Blood-to-tissue transport of (/sup 18/F)2-fluoro-2-deoxyglucose (FDG) and (/sup 11/C)O-methylglucose (CMG) was compared by dynamic positron emission tomography in four patients with recent ischemic infarcts and in three patients with intracerebral tumors. Local blood volume, tracer transport from tissue to blood, and FDG phosphorylation rates were also determined. A regional analysis of parametric images showed a close correlation of FDG and CMG transport rate constants in pathological tissue. Transport rates of FDG and CMG showed correspondingly less asymmetric remote effects than FDG phosphorylation rates. Transport rate constants were consistently higher for FDG than for CMG in pathological and normal tissue, in accordance with the higher affinity of carrier enzymes to FDG. There was a significant correlation between fitted regional blood volume values and correspondence of average absolute values with both tracers. It is concluded that dynamic FDG PET for measurement of cerebral glucose metabolism is also useful to measure alterations of hexose transport and local blood volume in pathological tissue.

• Research Organization: Max-Planck-Institut fuer Neurologische Forschung, Koeln (Germany, F.R.)
• OSTI ID: 6499660
• Journal Information: J. Cereb. Blood Flow Metab.; (United States), Journal Name: J. Cereb. Blood Flow Metab.; (United States) Vol. 9:1; ISSN JCBMD
• Country of Publication: United States
• Language: English

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550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD FLOW
BODY
BODY FLUIDS
BRAIN
CARBOHYDRATES
CARBON 11
CARBON ISOTOPES
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM
CHEMICAL REACTIONS
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
FLUORINE 18
FLUORINE ISOTOPES
HEXOSES
HOURS LIVING RADIOISOTOPES
ISCHEMIA
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MATERIALS
MEMBRANE TRANSPORT
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PHOSPHORYLATION
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
RADIOPHARMACEUTICALS
SACCHARIDES
TOMOGRAPHY
VASCULAR DISEASES