Response of murine jejunal crypts to single doses of cyclophosphamide and radiation. [Mice; whole-body. gamma. irradiation]

Journal Article · Sun Jan 01 04:00:00 EST 1978 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(78)90071-8· OSTI ID:6754718

Moore, J V; Hendry, J H

The survival of whole crypts in the murine jejunum has been measured after treatment by single-dose cyclophosphamide and whole-body irradiation. Increasing the dose of drug used in the combination from 0 to 450 mg kg-/sup 1/ reduced the surviving fraction of crypts by only a factor of 2, and a D/sub 0/ value of approximately 540 mg kg-/sup 1/ for survival of cryptogenic cells was deduced. Crypt survival also varied with interval between modalities, it was least when a high dose of drug was given 5 min or 8 hr before irradiation, with higher survival at intermediate times. When cyclophosphamide was administered 4 to 6 days before irradiation, a slight sparing effect was observed relative to crypt survival after irradiation alone. Results are discussed in terms of the sensitivity and capacity for recovery of those cells responsible for the regeneration of damaged crypts.

• Research Organization: Christie Hospital and Holt Radium Inst., Manchester, Eng.
• OSTI ID: 6754718
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 4:5/6; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ALKYLATING AGENTS
ANIMAL CELLS
ANIMALS
ANTIMITOTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
CESIUM 137
CESIUM ISOTOPES
CRYPT CELLS
DIGESTIVE SYSTEM
DRUGS
ELECTROMAGNETIC RADIATION
ENDOXAN
EXTERNAL IRRADIATION
GAMMA RADIATION
GASTROINTESTINAL TRACT
INJURIES
INTESTINES
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
MAMMALS
MICE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RECOVERY
RODENTS
SMALL INTESTINE
SOMATIC CELLS
SURVIVAL CURVES
TIME DEPENDENCE
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES