Interaction of irradiation and Adriamycin in intestinal crypt cells

Conference · Wed Aug 01 04:00:00 EDT 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:5340014

Ross, G Y; Phillips, T L; Goldstein, L S

The intestinal crypt cell assay was used to evaluate Adriamycin (ADR) and radiation injury in LAF/sub 1/ mice. The MTD (LD/sub 01///sub 60/) for ADR was 8 mg/kg. Crypt cell survival was reduced to 30% of the level of survival after radiation alone when drug was given at the MTD 2 h before or 3 h after irradiation. Determination of crypt cell survival from -48 to +48 h relative to 1210 rad showed little fluctuation and no evidence of a time interval yielding enhanced response. When a radiation survival curve was measured 2 h after a dose of 8 mg/kg, it paralleled the control curve with a shift toward lower radiation doses reflecting a 70% cell kill by drug. The 3 h split dose survival ratio of 4 to 6 was similar to the control values in two separate experiments. ADR appears to be toxic to intestinal crypt cells, but does not inhibit repair of radiation injury.

• Research Organization: Univ. of California, San Francisco
• DOE Contract Number: EY-76-C-03-1012
• OSTI ID: 5340014
• Conference Information: Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:8
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
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560152 -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
ANTIBIOTICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CESIUM 137
CESIUM ISOTOPES
CRYPT CELLS
DATA
DATA FORMS
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
DOSES
DOXORUBICIN
DRUGS
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GASTROINTESTINAL TRACT
INFORMATION
INJECTION
INTAKE
INTESTINES
INTRAPERITONEAL INJECTION
IRRADIATION
ISOLATED VALUES
ISOTOPES
MAMMALS
MICE
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
RODENTS
SMALL INTESTINE
SOMATIC CELLS
SURVIVAL CURVES
TIME DEPENDENCE
TOXICITY
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES