Interaction of radiation and cis-diamminedichloroplatinum (II) in intestinal crypt cells

Conference · Wed Aug 01 04:00:00 EDT 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:5236186

Luk, K H; Ross, G Y; Phillips, T L; Goldstein, L S

The effect of radiation and cis-platinum in combination was studied in the intestinal crypt cell survival system of the LAF/sub 1/ mouse. The drug LD/sub 50///sub 60/ was 22 mg/kg and the maximum tolerated dose (MTD) (LD/sub 01/) was 13 mg/kg. That dose caused 80% cell kill when given either 3 h after or 2 h before a dose of 1100 rad. When the MTD was given from -48 to +48 hrs relative to a dose of 1110 rad, survival fluctuated with minima at -12 h, 0 and +12 h. A radiation survival curve determined 2 hrs after an MTD drug dose was parallel to the control, but shifted to lower doses due to cell kill. The extrapolated D/sub Q/ was 280 rad, but the split dose survival ratio was only 1.3 compared to a control value of 7 at the same survival level. A repeat experiment with B/sub 6/AF/sub 1/ mice yielded a survival ratio of 3 vs 6 for controls. Cis-platinum may reduce repair of radiation injury, as well as kill intestinal crypt cells.

• Research Organization: Univ. of California, San Francisco
• OSTI ID: 5236186
• Conference Information: Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:8
• Country of Publication: United States
• Language: English

Related Subjects

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CELL KILLING
CESIUM 137
CESIUM ISOTOPES
COMPLEXES
CRYPT CELLS
DATA
DATA FORMS
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GAMMA RADIATION
GASTROINTESTINAL TRACT
INFORMATION
INTESTINES
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOTOPES
MAMMALS
MICE
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANS
PLATINUM COMPLEXES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
RODENTS
SMALL INTESTINE
SOMATIC CELLS
SURVIVAL CURVES
TIME DEPENDENCE
TRANSITION ELEMENT COMPLEXES
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES