Interaction of irradiation and BCNU in intestinal crypt cells
Survival of intestinal crypt cells was used to evaluate radiation and BCNU injury in LAF/sub 1/ mice. A dose of 25 mg/kg reduced the crypt cell survival to 35% of irradiated control levels, if BCNU was given 3 hr post-irradiation. Drug was more effective when given pre-irradiation from -18 to -2 hr than post-irradiation (1210 rad) from 3 to 48 hr. When a radiation survival curve was determined 2 hr after the MTD dose, the slope was similar to controls, but a shift was caused by cell kill. When BCNU was given 2 hr before a 3 hr split-radiation, the survival ratio was 4 to 7 which was comparable to the control values. Although BCNU appears to enhance radiation cell kill when given before radiation, it does not appear to inhibit the repair of radiation-induced damage. Irradiation may alter the repair mechanism of cells damaged by BCNU.
- Research Organization:
- Univ. of California, San Francisco
- DOE Contract Number:
- EY-76-C-03-1012
- OSTI ID:
- 5333963
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 5:9; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CELL PROLIFERATION
CESIUM 137
CESIUM ISOTOPES
COMPARATIVE EVALUATIONS
CRYPT CELLS
DATA
DATA FORMS
DIGESTIVE SYSTEM
DOSES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GAMMA RADIATION
GASTROINTESTINAL TRACT
INFORMATION
INJURIES
INTESTINES
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOTOPES
MAMMALS
MICE
NITROSO COMPOUNDS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
RODENTS
SMALL INTESTINE
SOMATIC CELLS
SURVIVAL CURVES
TIME DEPENDENCE
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES