Metabolism of /sup 241/Am citrate relative to age

Journal Article · Wed Jan 01 04:00:00 EST 1975 · Radiat. Res.; (United States)

OSTI ID:6754356

Mahlum, D D; Sikov, M R

Animal age has a marked influence on the metabolism of a number of radionuclides, although few data are available for /sup 241/Am. Therefore its deposition and retention were determined at intervals after intravenous injection in adult and weanling and intracardial injection in newborn rats. Doses of 1 and 10 ..mu..Ci/kg body weight were used; no dose-related effect on deposition or retention were found. The adult liver contained about half of the dose at one day postinjection and the weanling and newborn livers 10 and 18%, respectively. The rate of loss, however, was more rapid in the adult resulting in 16,7 and 12% remaining at 14 days in the adult, weanling and newborn livers respectively. Femoral deposition was highest in the weanlings and lowest in the newborns, presumably reflecting the relative rates of active mineralization occuring at these ages. The ratio of the concentrations, skull:femur at one day was one for newborns, 0.5 for weanlings and 0.7 for adults. Since little /sup 241/Am was lost from the skeleton and minimal growth of the skull occured, the ratio had increased for all ages by 14 days because of growth of the femur. There was little effect of age on the fraction of the dose deposited in other tissues.

• Research Organization: Battelle Pacific Northwest Labs., Richland, WA
• DOE Contract Number: AT(45-1)-1830
• OSTI ID: 6754356
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 62; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ADULTS
AGE DEPENDENCE
ALPHA DECAY RADIOISOTOPES
AMERICIUM 241
AMERICIUM ISOTOPES
ANIMALS
BIOLOGICAL LOCALIZATION
BODY
DEPOSITION
DIGESTIVE SYSTEM
DOSES
FEMUR
GLANDS
HEAVY NUCLEI
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPES
LIVER
MAMMALS
NEONATES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIATION DOSES
RADIOACTIVITY
RADIOISOTOPES
RATS
RETENTION
RODENTS
SKELETON
SKULL
TIME DEPENDENCE
VERTEBRATES
YEARS LIVING RADIOISOTOPES