Distribution and retention of /sup 241/Am in the baboon
The distribution, retention, and excretion of intravenously injected /sup 241/Am citrate have been investigated in a nonhuman primate. Seven adult female Kenya baboons which had been given 0.2 ..mu..Ci/kg were studied for 817 days by a combination of techniques: (a) external counting of 60-keV ..gamma.. of /sup 241/Am in vivo in both whole-body and partial-body geometries, (b) bioassay of liver and skull biopsy samples, and (c) radioanalysis of /sup 241/Am in excreta and baboon tissues at sacrifice. The data thus far confirm previously reported results that the major initial deposition sites of soluble /sup 241/Am in the baboon are the skeleton (35% of the injected dose (percentage ID) at 1 day) and liver (31% ID at 1 day). The elimination rate of /sup 241/Am from the liver was fairly rapid at 2.5%/day (T/sub 1/2/ = 28 days), whereas the retention of /sup 241/Am in bone was long (at least several years). Americium-241 excreted during the first week after injection was detected principally in the urine, whereas the majority of Am excreted during the following 7 weeks was in feces, corresponding in the most part to elimination of Am from the liver. Microlocalization of Am in various soft tissues indicates general agreement with results previously reported for other species. However, americium in the baboon ovary at late times after injection is found as highly focalized sources, occurring principally in the outer cortical regions and associated with concretic structures. The implications of the findings of these studies with respect to metabolic parameters used for radiation dose calculations in man are discussed.
- Research Organization:
- New York Univ., New York
- OSTI ID:
- 5340240
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 81:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
AMERICIUM 241
AMERICIUM ISOTOPES
ANIMALS
APES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL WASTES
BLOOD-PLASMA CLEARANCE
BODY
BODY FLUIDS
CLEARANCE
DATA
DATA FORMS
DIGESTIVE SYSTEM
DISTRIBUTION
DOSES
EXCRETION
EXPERIMENTAL DATA
FECES
FEMALE GENITALS
GLANDS
GONADS
HEAVY NUCLEI
INFORMATION
ISOLATED VALUES
ISOTOPES
LIVER
MAMMALS
MATERIALS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANS
OVARIES
PRIMATES
RADIATION DOSES
RADIATION EFFECTS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RETENTION
SKELETON
SKULL
TISSUE DISTRIBUTION
URINE
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES