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Polonium metabolism in adult female baboons

Journal Article · · Radiation Research; (United States)
DOI:https://doi.org/10.2307/3578817· OSTI ID:6550980
 [1];  [2];  [3]; ;  [4]
  1. Malcolm Pirnie, Inc., Cranbury, NJ (United States)
  2. S. Cohen Associates, Inc., McLean, VA (United States)
  3. Lawrence Livermore National Lab., CA (United States)
  4. New York Univ. Medical Center, Tuxedo, NY (United States)
+ Show Author Affiliations
The biokinetics of polonium in nonhuman primates (Papio anubis) has been studied after intravenous injection of [sup 210]Po citrate. The urinary excretion of polonium in the baboon could be described by a single exponential function with a half-time of 15.6 days. Excretion fractions of polonium were found to be markedly different from those reported for other species, including humans. Polonium-210 was found to be distributed throughout the soft tissues of the baboon with 29% of the injected polonium being deposited in liver, 7% in kidneys and 0.6 in spleen. Retention of polonium in all tissues exhibited single exponential functions; however, the biological half-times were variable, ranging from 15 to 50 days. 23 refs., 9 figs., 10 tabs.
DOE Contract Number:
AC04-76DP00053
OSTI ID:
6550980
Journal Information:
Radiation Research; (United States), Journal Name: Radiation Research; (United States) Vol. 137:2; ISSN 0033-7587; ISSN RAREAE
Country of Publication:
United States
Language:
English

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Related Subjects

560160* -- Radionuclide Effects
Kinetics
& Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALPHA DECAY RADIOISOTOPES
ANIMALS
BABOONS
BODY
CLEARANCE
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
EVEN-EVEN NUCLEI
EXCRETION
HEAVY NUCLEI
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
MAMMALS
METABOLISM
MONKEYS
NANOSEC LIVING RADIOISOTOPES
NUCLEI
ORGANS
POLONIUM 210
POLONIUM ISOTOPES
PRIMATES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RETENTION
TISSUE DISTRIBUTION
VERTEBRATES