Primate polonium metabolic models and their use in estimation of systemic radiation doses from bioassay data

Thesis/Dissertation · Sun Jan 01 04:00:00 EST 1989

OSTI ID:6155905

Fellman, A

A Polonium metabolic model was derived and incorporated into a Fortran algorithm which estimates the systemic radiation dose from {sup 210}Po when applied to occupational urine bioassay data. The significance of the doses estimated are examined by defining the degree of uncertainty attached to them through comprehensive statistical testing procedures. Many parameters necessary for dosimetry calculations, were evaluated from metabolic studies of {sup 210}Po in non-human primates. Two tamarins and six baboons were injected intravenously with {sup 210}Po citrate. Excreta and blood samples were collected. Five of the baboons were sacrifice at times ranging from 1 day to 3 months post exposure. Complete necropsies were performed and all excreta and the majority of all skeletal and tissue samples were analyzed radiochemically for their {sup 210}Po content. The {sup 210}Po excretion rate in the baboon was more rapid than in the tamarin. The biological half-time of {sup 210}Po excretion in the baboon was approximately 15 days while in the tamarin, the {sup 210}Po excretion rate was in close agreement with the 50 day biological half-time predicted by ICRP 30. Excretion fractions of {sup 210}Po in the non-human primates were found to be markedly different from data reported elsewhere in other species, including man.

• Research Organization: New York Univ., NY (USA)
• OSTI ID: 6155905
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALGORITHMS
ALPHA DECAY RADIOISOTOPES
ANIMALS
BABOONS
BIOASSAY
BIOLOGICAL HALF-LIFE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBOXYLIC ACID SALTS
CITRATES
DAYS LIVING RADIOISOTOPES
DOSES
EVEN-EVEN NUCLEI
HEAVY NUCLEI
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MATHEMATICAL LOGIC
MATHEMATICAL MODELS
METABOLISM
MONKEYS
NANOSEC LIVING RADIOISOTOPES
NUCLEI
OCCUPATIONAL EXPOSURE
POLONIUM 210
POLONIUM ISOTOPES
PRIMATES
RADIATION DOSES
RADIOISOTOPES
URINE
VERTEBRATES
WASTES