Distribution and retention of /sup 243/ /sup 244/Cm in the adult baboon
The metabolism of /sup 243/ /sup 244/Cm citrate has been studied in six adult female baboons for periods ranging up to 26 months after intravenous injection. In vivo measurements with ..gamma..-ray scintillation detectors were used to estimate parameters of deposition and retention of /sup 243/ /sup 244/Cm for the total body and specific organ sites. In addition, /sup 243/ /sup 244/Cm was measured in urine, feces, blood, and biopsy samples of liver. Curium-243,244 leaves the blood rapidly. The primary sites of early deposition are skeleton and liver. The retention of /sup 243/ /sup 244/Cm in bone is protracted with a half-time of several years, while that in liver is about 40 days. Approximately 7% of the injected dose is excreted in the urine during the first 24 h. Curium-243,244 eliminated from the liver appears to be excreted predominantly in feces as in the case for /sup 241/Am.
- Research Organization:
- New York Univ., NY
- OSTI ID:
- 6597735
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 85:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
APES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BIOPSY
BLOOD
BODY
BODY FLUIDS
CARBOXYLIC ACID SALTS
CITRATES
CURIUM 243
CURIUM 244
CURIUM ISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
FECES
FEMALES
GLANDS
HEAVY NUCLEI
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPES
LIVER
MAMMALS
MATERIALS
MEASURING INSTRUMENTS
NAI DETECTORS
NUCLEI
ORGANS
PRIMATES
RADIATION DETECTORS
RADIOISOTOPES
RADIONUCLIDE KINETICS
SCINTILLATION COUNTERS
SKELETON
SOLID SCINTILLATION DETECTORS
TISSUE DISTRIBUTION
URINE
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES