Distribution, retention and metabolic modelling of curium in the baboon

Thesis/Dissertation · Thu Jan 01 04:00:00 EST 1981

OSTI ID:5528389

Lo Sasso, T J

This research describes the metabolism of /sup 243,244/Cm in nine adult female baboons following exposure by intravenous injection. Curium-243,244 was administered to each baboon as a single injection of curium citrate in 0.08 M citric acid-sodium citrate buffer solution at pH 3.5 in dosage ranging from 0.053 to 0.220 ..mu..Ci/kg. The behavior of quantitated by various methods including external in vivo whole body and partial body counting, bioassay of blood, urine and feces samples, liver biopsies, and post-mortem tissue analysis. Curium-243,244 rapidly passed from the blood to other tissues. At 1 hour and 24 hours after injection the amounts circulating were approximately 10% and 1%, respectively. At 24 hours after injection about 70% of the /sup 243,244/Cm was located within soft tissues, probably associated to a large extend with extracellular fluid; the liver alone contained 32% of the injected activity at this time. During the first few weeks the content of /sup 243,244/Cm is soft tissues decreased sharply. As time progressed, significant deposition was noted predominantly in the liver and the skeleton. Approximately 20% of the injected activity was in the liver at 1 month and was retained there with a 40 day half-time. The skeleton reached a maximum burden of 57% by 100 days; the half-time observed in bone ranged from 4 to 16 years. Elimination of /sup 243,244/Cm from the body in the urine and feces was closely monitored. The structure and parameters of a model illustrating the interaction of seven internal compartments with respect to the translocation kinetics of /sup 243,244/Cm was derived based upon the above data. Solutions of the model represented as groups of exponential expressions have been derived for two specific time-related exposures. Investigation of the efficacy of diethylenetriaminepentaacetic acid (DTPA) to remove /sup 243,244/Cm from the body was also tested.

• OSTI ID: 5528389
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
APES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY
BODY FLUIDS
CURIUM 243
CURIUM 244
CURIUM ISOTOPES
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
FECES
HEAVY NUCLEI
IN VIVO
ISOTOPES
KINETICS
MAMMALS
MATERIALS
MATHEMATICAL MODELS
METABOLISM
NUCLEI
ORGANS
PRIMATES
RADIOISOTOPES
RADIONUCLIDE KINETICS
REACTION KINETICS
RETENTION
SKELETON
TISSUES
URINE
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES