Radioactivity studies progress report
Technical Report
·
OSTI ID:6454010
This research describes the metabolism of /sup 243/ /sup 244/Cm in nine adult female baboons following exposure by intravenous injection. Curium-243, 244 was administered to each baboon as a single injection of curium citrate in 0.08 M citric acid - sodium citrate buffer solution at pH 3.5 in dosage ranging from 0.053 to 0.220 ..mu..Ci/kg. The behavior of /sup 243/ /sup 244/Cm at these low experimental dosage levels has been quantitated by various methods including external in vivo whole body and partial body counting, bioassay of blood, urine and feces samples, liver biopsies, and post-mortem tissue analysis. The structure and parameters of a model illustrating the interaction of seven internal compartments with respect to the translocation kinetics of /sup 243/ /sup 244/Cm was derived based upon the above data. Solutions of the model represented as groups of exponential expressions have been derived for two specific time-related exposures. Finally, investigation of the efficacy of diethylene-triaminepentaacetic acid (DTPA) to remove /sup 233/ /sup 244/Cm from the body was tested.
- Research Organization:
- New York Univ., NY (USA). Medical Center
- DOE Contract Number:
- AS02-76EV03382
- OSTI ID:
- 6454010
- Report Number(s):
- DOE/EV/03382-19; COO-3382-19; ON: DE81027461
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
AMINO ACIDS
ANIMALS
APES
BIOLOGICAL HALF-LIFE
BIOLOGICAL LOCALIZATION
BIOLOGICAL PATHWAYS
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
CURIUM 243
CURIUM 244
CURIUM ISOTOPES
DATA
DRUGS
DTPA
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
EXCRETION
EXPERIMENTAL DATA
HEAVY NUCLEI
INFORMATION
ISOTOPES
MAMMALS
MATHEMATICAL MODELS
NUCLEI
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
PERFORMANCE TESTING
PRIMATES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPROTECTIVE SUBSTANCES
TESTING
TRANSLOCATION
VERTEBRATES
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
AMINO ACIDS
ANIMALS
APES
BIOLOGICAL HALF-LIFE
BIOLOGICAL LOCALIZATION
BIOLOGICAL PATHWAYS
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
CURIUM 243
CURIUM 244
CURIUM ISOTOPES
DATA
DRUGS
DTPA
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
EXCRETION
EXPERIMENTAL DATA
HEAVY NUCLEI
INFORMATION
ISOTOPES
MAMMALS
MATHEMATICAL MODELS
NUCLEI
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
PERFORMANCE TESTING
PRIMATES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPROTECTIVE SUBSTANCES
TESTING
TRANSLOCATION
VERTEBRATES
YEARS LIVING RADIOISOTOPES