Radioactivity studies. Progress report. Volume II. [Metabolic modelling of curuim in the baboon]

Technical Report · Tue Sep 01 04:00:00 EDT 1981

OSTI ID:5578752

Cohen, N

The metabolism of /sup 243/ /sup 244/Cm in nine adult female baboons following intravenous injection was studied. Curium-243,244 was administered as a single injection of curium citrate in dosages of 0.053 to 0.220 ..mu..Ci/kg. The behavior of /sup 243/ /sup 244/Cm at these low dosages was quantitated by external whole-body and partial-body counting, bioassay of blood, urine and feces samples, liver biopsies, and post-mortem tissues analysis. Curium-243,244 rapidly passed from the blood to other tissues. At 1 and 24 h after injection, the amounts circulating were 10% and 1%, respectively. At 24 h after injection 70% of the /sup 243/ /sup 244/Cm was located within soft tissues, probably associated with extracellular fluid; the liver alone contained 32% of the injected activity. During the first weeks the content of /sup 243/ /sup 244/Cm in soft tissues decreased sharply. As time progressed, significant deposition was noted in the liver and the skeleton. Approximately 20% of the injected activity was in the liver at 1 month with a 40 day half-time. The skeleton reached a maximum burden of 57% by 100 days; the half-time observed in bone was 4 to 16 y. During the first 24 h, 10% of the injected activity appeared in the urine decreasing to 0.1%/day at 30 days and 0.01%/day at 200 days. Fecal excretion increased reaching a maximum level at four weeks. The amount of /sup 243/ /sup 244/Cm excreted in the feces during the initial 4 to 5 months (approx. 20%) and the rate of elimination in the feces after the first month paralleled the retention in the liver indicating an hepatic-biliary-fecal pathway. A model illustrating the interaction of seven internal compartments with respect to the translocation kinetics of /sup 243/ /sup 244/Cm was derived based upon this data. Solutions of the model were derived for two specific time-related exposures.

• Research Organization: New York Univ., NY (USA). Medical Center
• DOE Contract Number: AS02-76EV03382
• OSTI ID: 5578752
• Report Number(s): DOE/EV/03382-20-Vol.2; ON: DE82007856
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
APES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CLEARANCE
CURIUM 243
CURIUM 244
CURIUM ISOTOPES
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
EXCRETION
EXPERIMENTAL DATA
FECES
FEMALES
GLANDS
GRAPHS
HEAVY NUCLEI
INFORMATION
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPES
LIVER
MAMMALS
MATERIALS
MATHEMATICAL MODELS
METABOLISM
NUCLEI
NUMERICAL DATA
ORGANS
PRIMATES
RADIOISOTOPES
RADIONUCLIDE KINETICS
SKELETON
TABLES
TISSUE DISTRIBUTION
URINE
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES