Placental transfer and distribution of /sup 241/Am in the rat
Journal Article
·
· Radiat. Res.; (United States)
The placental transfer and distribution of /sup 241/Am in the feto-placental system were studied in pregnant rats. Rats were injected intravenously with /sup 241/Am citrate at 15 or 18 days of gestation. Groups injected at 15 days of gestation were sacrificed 2, 24, 48, or 120 hr after injection, and the group injected at 18 days was sacrificed 24 hr after. The radioactivities of /sup 241/Am in fetus, fetal membrane, and placenta were determined, and its distribution in the feto-placental system was investigated by high-speed autoradiography using a silver-activated zinc sulfide-coated membrane as an intensifying screen. The deposition of /sup 241/Am in feto-placenta units increased with the number of days of gestation. Results of autoradiography revealed that major deposition sites of /sup 241/Am in the fetus are the skeleton and liver. Heavy deposition of /sup 241/Am in the yolksac splanchnopleure and its existence in the exocoelom strongly suggest that the yolk sac placenta plays an important role in the placental transfer of this nuclide.
- Research Organization:
- Akita Univ., Japan
- OSTI ID:
- 5706455
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 94:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
AMERICIUM 241
AMERICIUM ISOTOPES
ANIMALS
AUTORADIOGRAPHY
BODY
CARBOXYLIC ACID SALTS
CITRATES
DIGESTIVE SYSTEM
DISTRIBUTION
FETAL MEMBRANES
FETUSES
GLANDS
HEAVY NUCLEI
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPES
LIVER
MAMMALS
MEMBRANE TRANSPORT
MEMBRANES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PLACENTA
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
SKELETON
TISSUE DISTRIBUTION
VERTEBRATES
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
AMERICIUM 241
AMERICIUM ISOTOPES
ANIMALS
AUTORADIOGRAPHY
BODY
CARBOXYLIC ACID SALTS
CITRATES
DIGESTIVE SYSTEM
DISTRIBUTION
FETAL MEMBRANES
FETUSES
GLANDS
HEAVY NUCLEI
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPES
LIVER
MAMMALS
MEMBRANE TRANSPORT
MEMBRANES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PLACENTA
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
SKELETON
TISSUE DISTRIBUTION
VERTEBRATES
YEARS LIVING RADIOISOTOPES