Embryotoxicity and fetal toxicity of nickel in rats

Journal Article · Sun Jan 01 00:00:00 EST 1978 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(78)90017-0· OSTI ID:5370020

Sunderman, Jr, F W; Shen, S K; Mitchell, J M; Allpass, P R; Damjanov, I

Embryotoxicity and fetal toxicity of nickel chloride (NiCl/sub 2/) and nickel subsulfide (Ni/sub 3/S/sub 2/) were studied in Fischer rats. Injection of NiCl/sub 2/ (16 mg of Ni/kg, im) on Day 8 of gestation reduced the man number of live pups per dam and resulted in diminisehd body weights of fetuses on Day 20 of gestation and of weanlings at 4 to 8 weeks after birth. Injection of Ni/sub 2/S/sub 2/ (80 mg of Ni/kg, im) on Day 6 of gestation reduced the mean number of live pups per dam. No congenital anomalies were found in fetuses from any Ni-treated dams, including dams that recieved 10 im injections of NiCl/sub 2/ (2 mg of Ni/kg, twice daily, on Days 6 to 10 of gestation). /sup 63/NiCl/sub 2/ (12 mg of Ni/kg, im) was administered to a group of nonpregnant female rats and to groups of pregnant rats on Day 8 or 18 of gestation. After 24 hr, the relative concentrations of /sup 63/Ni in tissues were: kidney > serum > adrenal approx. = lung approx. = ovary > spleen approx. = heart approx. = liver > skeletal muscle. Pituitary /sup 63/Ni concentrations were much higher in pregnant rats than in non-pregnant females. /sup 63/Ni concentrations in products of conception (embryos and embryonic membranes) on Day 9 and in placentas on Day 19 were equivalent to /sup 63/Ni concentrations in adrenal, lung, and ovary tissues of the dams. Autoradiography of fetuses and placentas on Day 19 of gestation showed /sup 63/Ni localization in fetal urinary bladders and in the basal laminae and yolk sacs of the placentas. These studies show (a) that im injection of NiCl/sub 2/ and Ni/sub 3/S/sub 2/ during early gestation causes embryonic mortality at dosages that do not cause maternal mortality, and (b) that /sup 63/Ni(II) can cross the feto-maternal barriers and enter the fetuses during late gestation.

• Research Organization: Univ. of Connecticut, Farmington
• OSTI ID: 5370020
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Vol. 43
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
EMBRYOS
TOLERANCE
FETUSES
NICKEL
TOXICITY
RATS
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
FETAL MEMBRANES
ISOLATED VALUES
MORTALITY
NICKEL 63
NICKEL CHLORIDES
NICKEL SULFIDES
ONTOGENESIS
RADIONUCLIDE KINETICS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHALCOGENIDES
CHLORIDES
CHLORINE COMPOUNDS
DATA
DATA FORMS
DISTRIBUTION
ELEMENTS
EVEN-ODD NUCLEI
HALIDES
HALOGEN COMPOUNDS
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MEMBRANES
METALS
NICKEL COMPOUNDS
NICKEL ISOTOPES
NUCLEI
NUMERICAL DATA
RADIOISOTOPES
RODENTS
SULFIDES
SULFUR COMPOUNDS
TRANSITION ELEMENT COMPOUNDS
TRANSITION ELEMENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560151* - Radiation Effects on Animals- Man
550601 - Medicine- Unsealed Radionuclides in Diagnostics
551000 - Physiological Systems