The disposition of /sup 14/C-trimethyltin in the pregnant rat and fetus

Journal Article · Tue Feb 28 23:00:00 EST 1989 · Neurotoxicol. Teratol.; (United States)

DOI:https://doi.org/10.1016/0892-0362(89)90057-3· OSTI ID:5925628

Lipscomb, J C; Paule, M G; Slikker, W Jr

Trimethyltin (TMT) is a potent neurotoxicant. For unknown reasons, age at exposure to TMT may dramatically influence the severity of TMT-induced neuropathology. We have demonstrated previously that radiolabel derived from (/sup 14/C)-TMT given to pregnant dams on gestational day (GD) 17 is found in fetal brain and blood. The present study was designed to determine the distribution of radiolabel derived from (14C)-TMT to brain and other tissue in fetuses from dams dosed on either GD 12 or 17 with 7.0 mg/kg TMT chloride. Radioactivity in GD 12 and GD 17 maternal whole blood peaked 1 hour after IP treatment. Whole blood elimination half-lives were 12-15 days. Peak radiolabel concentrations in GD 12 maternal and fetal brain were only 11-30% of those from GD 17 animals, however, peak fetal brain concentrations of radiolabel were not different from their respective maternal brain concentrations. Radiolabel concentrations in liver, kidney, and adrenal of GD 17 dams were higher than those in corresponding GD 12 tissues. Combined urinary and fecal elimination of radiolabel for two weeks after dosing accounted for 31 and 22% of the GD 12 and 17 doses, respectively. It appears that gestational age influences the distribution and elimination of TMT in the rat.

• Research Organization: National Center for Toxicological Research, Jefferson, AR (USA)
• OSTI ID: 5925628
• Journal Information: Neurotoxicol. Teratol.; (United States), Journal Name: Neurotoxicol. Teratol.; (United States) Vol. 11:2; ISSN NETEE
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL HALF-LIFE
CARBON 14 COMPOUNDS
DISTRIBUTION
FETUSES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
METABOLISM
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
PREGNANCY
RATS
RODENTS
TIN COMPOUNDS
TISSUE DISTRIBUTION
TOXICITY
TRACER TECHNIQUES
VERTEBRATES