(1-/sup 11/C) DL-valine, a potential pancreas-imaging agent. [Rats, hamsters, rabbits, dogs]
There is a great need for a better pancreas-imaging agent. Studies with (1-/sup 14/C) DL-valine have shown this amino acid to have a high pancreatic specificity in the four animal species examined. The tissue distribution was almost optimal by 30 min after injection, and no carrier effect was observed through a dose of 5 mg/kg. (1-/sup 11/C) DL-Valine was synthesized in amounts up to 363 mCi using a rapid (T/sub /sup 1///sub 2// = 20.4 min for C-11), high-temperature, high-pressure modification of the Buecherer-Strecker amino acid synthesis. Purification was by anion-exchange followed by cation-exchange chromatography. (I-/sup 11/C) DL-Valine was obtained in a 70 percent chemical yield with a total synthesis and purification time of 45 min. Studies in animals have demonstrated that it is a potentially useful new agent for clinical pancreatic imaging.
- Research Organization:
- Oak Ridge Associated Universities, TN
- OSTI ID:
- 6753003
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 19:1; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACIDS
CHROMATOGRAPHY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DOGS
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
GLANDS
HAMSTERS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PANCREAS
PURIFICATION
RABBITS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RATS
RODENTS
SCINTISCANNING
SEPARATION PROCESSES
TISSUE DISTRIBUTION
VALINE
VERTEBRATES