(1-/sup 11/C) DL-valine, a potential pancreas-imaging agent. [Rats, hamsters, rabbits, dogs]
There is a great need for a better pancreas-imaging agent. Studies with (1-/sup 14/C) DL-valine have shown this amino acid to have a high pancreatic specificity in the four animal species examined. The tissue distribution was almost optimal by 30 min after injection, and no carrier effect was observed through a dose of 5 mg/kg. (1-/sup 11/C) DL-Valine was synthesized in amounts up to 363 mCi using a rapid (T/sub /sup 1///sub 2// = 20.4 min for C-11), high-temperature, high-pressure modification of the Buecherer-Strecker amino acid synthesis. Purification was by anion-exchange followed by cation-exchange chromatography. (I-/sup 11/C) DL-Valine was obtained in a 70 percent chemical yield with a total synthesis and purification time of 45 min. Studies in animals have demonstrated that it is a potentially useful new agent for clinical pancreatic imaging.
- Research Organization:
- Oak Ridge Associated Universities, TN
- OSTI ID:
- 6753003
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 19:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CARBON 11
SCINTISCANNING
TISSUE DISTRIBUTION
PANCREAS
CHROMATOGRAPHY
DOGS
HAMSTERS
PURIFICATION
RABBITS
RATS
VALINE
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON ISOTOPES
CARBOXYLIC ACIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
GLANDS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RODENTS
SEPARATION PROCESSES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics