Carbon-11-labeled amino acids for the rectilinear and positron tomographic imaging of the human pancreas

Journal Article · Fri Jun 01 04:00:00 EDT 1979 · J. Nucl. Med.; (United States)

OSTI ID:5734035

Huebner, K F; Andrews, G A; Buonocore, E; Hayes, R L; Washburn, L C; Collmann, I R; Gibbs, W D

Modification of the Buecherer-Strecker amino acid synthesis facilitated the production of DL-(/sup 11/C)tryptophan and DL-(/sup 11/C)valine for clinical trials in patients with proven or suspected pancreatic disease. Examples of rectilinear scans and tomographic images of the pancreas are presented in this initial paper. Positron computed tomography was done with the ORTEC ECAT system. Rapid localization of these C-11-labeled amino acids and fast clearance from the plasma permit almost immediate examination following i.v. injection. Illustrative images include the normal pancreas, pancreatitis, and pancreatic carcinoma. The use of positron tomography with C-11-labeled DL-tryptophan and DL-valine appears to offer a new and promising diagnostic modality for the detection and study of pancreatic diseases.

• Research Organization: Oak Ridge Associated Universities, TN
• DOE Contract Number: EY-76-C-05-0033
• OSTI ID: 5734035
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:6; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
AZOLES
BODY
CARBOXYLIC ACIDS
CAT SCANNING
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
ENDOCRINE GLANDS
GLANDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IMAGES
INDOLES
LABELLED COMPOUNDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PANCREAS
PHOTON TRANSMISSION SCANNING
PYRROLES
TOMOGRAPHY
TRYPTOPHAN
VALINE