High-level production of C-11-carboxyl-labeled amino acids. [For use in tumor and pancreatic imaging]
Carbon-11-labeled amino acids have significant potential as agents for positron tomographic functional imaging. We have developed a rapid, high-temperature, high-pressure modification of the Buecherer--Strecker amino acid synthesis and found it to be quite general for the production of C-11-carboxyl-labeled neutral amino acids. Production of C-11-carboxyl-labeled DL-tryptophan requires certain modifications in the procedure. Twelve different amino acids have been produced to date by this technique. Synthesis and chromatographic purification require approximately 40 min, and C-11-carboxyl-labeled amino acids have been produced in yields of up to 425 mCi. Two C-11-carboxyl-labeled amino acids are being investigated clinically for tumor scanning and two others for pancreatic imaging. Over 120 batches of the various agents have been produced for clinical use over a three-year period.
- Research Organization:
- Oak Ridge Associated Universities, Inc., TN (USA). Medical and Health Science Div.; Oak Ridge National Lab., TN (USA)
- Sponsoring Organization:
- USDOE Office of Environment, Safety and Health (EH)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 6298908
- Report Number(s):
- CONF-790321--4
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACIDS
CAT SCANNING
CHEMICAL PREPARATION
CHEMISTRY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DRUGS
ECAT SCANNING
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
GLANDS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PANCREAS
PHOTON EMISSION SCANNING
PHOTON TRANSMISSION SCANNING
RADIOACTIVE MATERIALS
RADIOCHEMISTRY
RADIOISOTOPES
RADIOPHARMACEUTICALS
SYNTHESIS
TOMOGRAPHY