DL-(carboxyl-/sup 11/C)tryptophan, a potential agent for pancreatic imaging; production and preclinical investigations
In animal studies, DL-(carboxyl-/sup 14/C)tryptophan (DL-Try(C-14)) showed a high specificity for the pancreas, which suggested the potential of DL-(carboxyl-/sup 11/C)tryptophan (DL-Try(C-11)) for clinical pancreatic imaging. The blood clearance and tissue uptake of the amino acid were very rapid, and no carrier effect was observed through a dose of 5 mg/kg. None of three transplanted hamster pancreatic adenocarcinomas that we studied showed a selective uptake of DL-Try(C-14) by the tumor, and none of the three enzymatic regimens investigated gave significant enhancement of the pancreatic specificity. Commercial L-Try(C-14) gave slightly better pancreatic specificity than the analogous racemic compound but without enough improvement to warrant attempts at optical resolution. DL-Try(C-11) was synthesized in amounts up to 325 mCi using a rapid, high-temperature, high-pressure modification of the Buecherer-Strecker amino acid synthesis. Yields ranged from 30 to 60%, and a total of 40 min was required for synthesis and chromatographic purification. DL-Try(C-11) thus appears to have significant potential as a clinical pancreas-imaging agent, particularly when used in conjunction with positron computerized transaxial tomography.
- Research Organization:
- Oak Ridge Associated Universities, TN
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5998799
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:8; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BLOOD-PLASMA CLEARANCE
BODY
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACID ESTERS
CARBOXYLIC ACIDS
CAT SCANNING
CHEMICAL PREPARATION
CLEARANCE
COUNTING TECHNIQUES
DATA
DATA FORMS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DOGS
DRUGS
ECAT SCANNING
ENDOCRINE GLANDS
ESTERS
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
FEASIBILITY STUDIES
GLANDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INDOLES
INFORMATION
ISOLATED VALUES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PANCREAS
PHOTON EMISSION SCANNING
PHOTON TRANSMISSION SCANNING
PYRROLES
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RATS
RODENTS
SCINTISCANNING
SYNTHESIS
TISSUE DISTRIBUTION
TOMOGRAPHY
TRYPTOPHAN
VERTEBRATES