DL-(carboxyl-/sup 11/C)tryptophan, a potential agent for pancreatic imaging; production and preclinical investigations
In animal studies, DL-(carboxyl-/sup 14/C)tryptophan (DL-Try(C-14)) showed a high specificity for the pancreas, which suggested the potential of DL-(carboxyl-/sup 11/C)tryptophan (DL-Try(C-11)) for clinical pancreatic imaging. The blood clearance and tissue uptake of the amino acid were very rapid, and no carrier effect was observed through a dose of 5 mg/kg. None of three transplanted hamster pancreatic adenocarcinomas that we studied showed a selective uptake of DL-Try(C-14) by the tumor, and none of the three enzymatic regimens investigated gave significant enhancement of the pancreatic specificity. Commercial L-Try(C-14) gave slightly better pancreatic specificity than the analogous racemic compound but without enough improvement to warrant attempts at optical resolution. DL-Try(C-11) was synthesized in amounts up to 325 mCi using a rapid, high-temperature, high-pressure modification of the Buecherer-Strecker amino acid synthesis. Yields ranged from 30 to 60%, and a total of 40 min was required for synthesis and chromatographic purification. DL-Try(C-11) thus appears to have significant potential as a clinical pancreas-imaging agent, particularly when used in conjunction with positron computerized transaxial tomography.
- Research Organization:
- Oak Ridge Associated Universities, TN
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5998799
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 20:8
- Country of Publication:
- United States
- Language:
- English
Similar Records
High-level production of C-11-carboxyl-labeled amino acids. [For use in tumor and pancreatic imaging]
Carbon-11-labeled amino acids for the rectilinear and positron tomographic imaging of the human pancreas
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
CARBON 11
ECAT SCANNING
RADIOPHARMACEUTICALS
SCINTISCANNING
CARBOXYLIC ACID ESTERS
DOGS
RADIONUCLIDE KINETICS
PANCREAS
BIOLOGICAL LOCALIZATION
CHEMICAL PREPARATION
TISSUE DISTRIBUTION
RATS
TRYPTOPHAN
BLOOD-PLASMA CLEARANCE
EXPERIMENTAL DATA
FEASIBILITY STUDIES
ISOLATED VALUES
AMINO ACIDS
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON ISOTOPES
CARBOXYLIC ACIDS
CAT SCANNING
CLEARANCE
COUNTING TECHNIQUES
DATA
DATA FORMS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ENDOCRINE GLANDS
ESTERS
EVEN-ODD NUCLEI
GLANDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INDOLES
INFORMATION
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHOTON EMISSION SCANNING
PHOTON TRANSMISSION SCANNING
PYRROLES
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RODENTS
SYNTHESIS
TOMOGRAPHY
VERTEBRATES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
550601 - Medicine- Unsealed Radionuclides in Diagnostics
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials