Effect of TLV levels of SO/sub 2/ and H/sub 2/SO/sub 4/ on bronchial clearance in exercising man

Journal Article · Sun Jan 01 04:00:00 EST 1978 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1978.10667304· OSTI ID:6741144

Newhouse, N T ^[1]; Dolovich, M; Obminski, G; Wolff, R K

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1. St. Joseph's Hospital Respiratory Unit, Hamilton, Ont.

Pulmonary mucociliary function was assessed following exposure to industrial threshold limit values (TLV) of sulfur dioxide (5 ppM SO/sub 2/) and sulfuric acid mist (1 mg/m/sup 3/ H/sub 2/SO/sub 4/). Bronchial clearance was measured in two sets of ten healthy exercising non-smoking adults under control and exposure conditions. A /sup 99m/Tc-albumin saline aerosol (MMD 3 ..mu..m) was inhaled as a bolus in late inspiration under controlled conditions to produce reproducible deposition in large airways. Lung retention of radioactivity was quantified using a gamma camera and computer analysis. Clearance was significantly faster (P < .05) on exposure to both SO/sub 2/ and H/sub 2/SO/sub 4/ compared to control values. Maximum mid-expiratory flow rates (MMFR) were significantly reduced (P < .01) on exposure to SO/sub 2/ (mean decrease 8.5%), but only slightly reduced for H/sub 2/SO/sub 4/ (1.4%). The speeding in clearance was probably an irritant response in both cases. For SO/sub 2/ the response appeared predominantly reflex, while H/sub 2/SO/sub 4/ showed evidence of a direct effect.

• OSTI ID: 6741144
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 33:1; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism &amp; Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ALBUMINS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
BRONCHI
CHALCOGENIDES
COLLOIDS
DISPERSIONS
EXERCISE
HOURS LIVING RADIOISOTOPES
HYDROGEN COMPOUNDS
INDUSTRY
INORGANIC ACIDS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LUNGS
MAMMALS
MAN
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PRIMATES
PROTEINS
RADIOISOTOPES
RESPIRATORY SYSTEM
SOLS
STANDARDS
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES
SULFURIC ACID
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES