Effects of sulfur oxide pollutants on respiratory function, particle deposition and bronchial clearance. Final report
Technical Report
·
OSTI ID:5805721
The effects of sulfur oxide pollutants on respiratory function, particle deposition, and bronchial clearance were explored in a series of three studies, two on donkeys and one on humans. In the first study, the effects of one-hour inhalation exposures to 0.3 - 0.6 micrograms H/sub 2/SO/sub 4/ and (NH/sub 4/)/sub 2/SO/sub 4/ aerosols in the donkey were studied in terms of alterations in pulmonary flow resistance and dynamic compliance, and changes in the regional deposition and tracheobronchial mucociliary clearance of an inert test aerosol. In the second study, the effect of chronic inhalation exposures to sulfuric acid mist upon mucociliary clearance from the lungs was studied, using the donkey as an analogue for man. Four animals were exposed one hour per day, five days per week, for six months; two to a concentration of 102 micrograms/cu m, the other to 106 micrograms/cu m. In the final study, the mucociliary particle clearance and respiratory mechanics of twelve healty nonsmokers exposed to 1/2 micrometer H/sub 2/SO/sub 4/ at 0 (control), 100, 300, and 1,000 micrograms/cu m for one hour per day for four days were examined.
- Research Organization:
- New York Univ., NY (USA). Inst. of Environmental Medicine
- OSTI ID:
- 5805721
- Report Number(s):
- PB-81-168288
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
560306 -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AMMONIUM COMPOUNDS
AMMONIUM SULFATES
ANIMALS
BIOLOGICAL EFFECTS
BODY
BRONCHI
BURROS
CHALCOGENIDES
CLEARANCE
COLLOIDS
DISPERSIONS
EXCRETION
HYDROGEN COMPOUNDS
INHALATION
INORGANIC ACIDS
INTAKE
LABORATORY ANIMALS
LUNG CLEARANCE
LUNGS
MAMMALS
MAN
ORGANS
OXIDES
OXYGEN COMPOUNDS
PRIMATES
RESPIRATORY SYSTEM
SOLS
SULFATES
SULFUR COMPOUNDS
SULFUR OXIDES
SULFURIC ACID
TOXICITY
VERTEBRATES
560306 -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AMMONIUM COMPOUNDS
AMMONIUM SULFATES
ANIMALS
BIOLOGICAL EFFECTS
BODY
BRONCHI
BURROS
CHALCOGENIDES
CLEARANCE
COLLOIDS
DISPERSIONS
EXCRETION
HYDROGEN COMPOUNDS
INHALATION
INORGANIC ACIDS
INTAKE
LABORATORY ANIMALS
LUNG CLEARANCE
LUNGS
MAMMALS
MAN
ORGANS
OXIDES
OXYGEN COMPOUNDS
PRIMATES
RESPIRATORY SYSTEM
SOLS
SULFATES
SULFUR COMPOUNDS
SULFUR OXIDES
SULFURIC ACID
TOXICITY
VERTEBRATES