Effects of sulfuric acid aerosol on respiratory mechanics and mucociliary particle clearance in healthy nonsmoking adults

Journal Article · Wed Apr 01 04:00:00 EST 1981 · Am. Ind. Hyg. Assoc. J.; (United States)

DOI:https://doi.org/10.1080/15298668191419721· OSTI ID:6495594

Leikauf, G; Yeates, D B; Wales, K A; Spektor, D; Albert, R E; Lippmann, M

Ten healthy nonsmokers inhaled H/sub 2/SO/sub 4/ at 0 (control), 110, 330, and 980 ..mu..g/m/sup 3/ for one hour via nasal mask in random sequence on four separate days. Respiratory mechanical function was assessed before and after the H/sub 2/SO/sub 4/ exposure. A /sup 99m/Tc tagged Fe/sub 2/O/sub 3/ aerosol was inhaled approx. 10 min before each H/sub 2/SO/sub 4/ exposure. Thoracic retention of the deposited radioactivity was monitored using collimated scintillation detectors. A tracheal probe was used to determine the tracheal mucociliary trnsport rates (TMTR's) of local concentrations of activity. Bronchial mucociliary clearance was markedly altered in a dose dependent pattern in six of the individuals and in the group as a whole. The four individuals whose clearance times were not significantly affected by these H/sub 2/SO/sub 4/ exposures were each given an additional test with a 1000 ..mu..g/m/sup 3/ H/sub 2/SO/sub 4/ exposure preceding the tagged Fe/sub 2/O/sub 3/ aerosol. Three of them responded. Thus, 9 of 10 subjects had substantial changes in bronchial clearance times following H/sub 2/SO/sub 4/ exposures.

• Research Organization: New York Univ. Medicat Center, NY
• OSTI ID: 6495594
• Journal Information: Am. Ind. Hyg. Assoc. J.; (United States), Journal Name: Am. Ind. Hyg. Assoc. J.; (United States) Vol. 42:4; ISSN AIHAA
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADULTS
AEROSOLS
AGE GROUPS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
CLEARANCE
COLLOIDS
DISPERSIONS
EXCRETION
HOURS LIVING RADIOISOTOPES
HYDROGEN COMPOUNDS
INORGANIC ACIDS
INTERMEDIATE MASS NUCLEI
IRON COMPOUNDS
IRON OXIDES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNG CLEARANCE
LUNGS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PHYSIOLOGY
RADIOISOTOPES
RESPIRATION
RESPIRATORY SYSTEM
RETENTION
SOLS
SULFURIC ACID
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPOUNDS
YEARS LIVING RADIOISOTOPES