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Comparative irritant potency of inhaled sulfate aerosols: effects on bronchial mucociliary clearance. [Rabbits]

Journal Article · · Environ. Res.; (United States)

The effect of 1-hr oral inhalation exposures to submicrometer aerosols of ammonium bisulfate (NH/sub 4/HSO/sub 4/), ammonium sulfate ((NH/sub 4/)/sub 2/SO/sub 4/), and sodium sulfate (Na/sub 2/SO/sub 4/) upon mucociliary clearance from the bronchial tree of rabbits was examined. Exposures to NH/sub 4/HSO/sub 4/ at concentrations of approx. 600 to 1700 ..mu..g/m/sup 3/ produced a significant depression of clearance rate only at the highest exposure level. No significant effects were observed with the other sulfates at levels up to approx. 2000 ..mu..g/m/sup 3/. When results were compared to those from another study in this laboratory using sulfuric acid (H/sub 2/SO/sub 4/) aerosol, the ranking of irritant potency was H/sub 2/SO/sub 4/ > NH/sub 4/HSO/sub 4/ > (NH/sub 4/)/sub 2/SO/sub 4/, Na/sub 2/SO/sub 4/. Alteration in bronchial mucociliary clearance due to sulfate aerosols appears to be related to the deposition of (H/sup +/) on the mucus lining of conducting airways.

Research Organization:
New York Univ. Medical Center, NY
OSTI ID:
6133931
Journal Information:
Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 34:2; ISSN ENVRA
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ALKALI METAL COMPOUNDS
AMMONIUM COMPOUNDS
AMMONIUM SULFATES
ANIMALS
BIOLOGICAL EFFECTS
BRONCHI
CLEARANCE
COLLOIDS
COMPARATIVE EVALUATIONS
DATA
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
EXCRETION
EXPERIMENTAL DATA
HYDROGEN COMPOUNDS
INFORMATION
INHALATION
INORGANIC ACIDS
INTAKE
LUNG CLEARANCE
MAMMALS
NUMERICAL DATA
OXYGEN COMPOUNDS
PARTICLES
PARTICULATES
RABBITS
RESPIRATORY SYSTEM
SODIUM COMPOUNDS
SODIUM SULFATES
SOLS
SULFATES
SULFUR COMPOUNDS
SULFURIC ACID
VERTEBRATES