Dose-dependent effects of submicrometer sulfuric acid aerosol on particle clearance from ciliated human lung airways

Journal Article · Sun Jan 01 00:00:00 EST 1984 · Am. Ind. Hyg. Assoc. J.; (United States)

DOI:https://doi.org/10.1080/15298668491399802· OSTI ID:5516770

Leikauf, G D; Spektor, D M; Albert, R E; Lippmann, M

It was shown previously that 1 hr exposures to submicrometer sulfuric acid (H/sub 2/SO/sub 4/) aerosol at 100 and 1000 ..mu..g/m/sup 3/ altered the bronchial mucociliary clearance of monodisperse 7.6 ..mu..m MMAD /sup 99m/Tc-labelled ferric oxide (Fe/sub 2/O/sub 3/) in healthy, nonsmoking humans. The 7.6 ..mu..m particles were deposited in the larger bronchial airways, where submicrometer H/sub 2/SO/sub 4/ has very little deposition. To determine the extent that submicrometer H/sub 2/SOO/sub 4/ aerosol affects clearance from the more distal ciliated airways, the authors measured the clearance of a monodisperse 4.2 ..mu..m MMAD Fe/sub 2/O/sub 3/ aerosol in eight other healthy nonsmoking subjects. A greater fraction of 4.2 ..mu..m particles deposited in distal conductive airways. Bronchial mucociliary clearance was slower following 1 hr nasal H/sub 2/SO/sub 4/ inhalations at 100, 300 and 1000 ..mu..g/m/sup 3/ than after sham exposures, while mucociliary transport rates within the trachea and indices of respiratory mechanics were unchanged. A comparison of the effects of 1 h exposures at 100 ..mu..g/m/sup 3/ on the clearance of 7.6 and 4.2 ..mu..m particles suggests greater physiological response in distal ciliated airways than in larger central airways.

• Research Organization: New York Univ. Medical Center, NY
• OSTI ID: 5516770
• Journal Information: Am. Ind. Hyg. Assoc. J.; (United States), Vol. 45:5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
IRON OXIDES
LUNG CLEARANCE
PARTICULATES
RETENTION
SULFURIC ACID
BIOLOGICAL EFFECTS
AEROSOLS
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
ISOMERIC NUCLEI
LABELLED COMPOUNDS
LUNGS
MAN
TECHNETIUM 99
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CHALCOGENIDES
CLEARANCE
COLLOIDS
DATA
DISPERSIONS
EXCRETION
HOURS LIVING RADIOISOTOPES
HYDROGEN COMPOUNDS
INFORMATION
INORGANIC ACIDS
INTERMEDIATE MASS NUCLEI
IRON COMPOUNDS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PARTICLES
PRIMATES
RADIOISOTOPES
RESPIRATORY SYSTEM
SOLS
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)