Radiation-induced inhibition of compensatory renal growth in the weanling mouse kidney. [X rays]

Conference · Tue Aug 01 04:00:00 EDT 1978 · Radiology; (United States)

OSTI ID:6736702

Donaldson, S S; Moskowitz, P S; Canty, E L; Efron, B

Weanling mice were given 500, 1,000, 1,500, or 2,000 rads single-fraction renal irradiation immediately following unilateral nephrectomy and sacrificed 3 days or 3, 6, 12, or 24 weeks later. Inhibition of compensatory renal growth was related to both radiation dose and time following treatment; it was transient following 500 and 1,000 rads but persisted following 1,500 and 2,000 rads. Renal growth was inhibited more than body growth. These studies indicate that the weaning mouse kidney is more sensitive to radiation-induced inhibition of compensatory renal growth than adult mice or other rodents.

• Research Organization: Stanford Univ., CA
• OSTI ID: 6736702
• Conference Information: Journal Name: Radiology; (United States) Journal Volume: 128:2
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
AGE GROUPS
ANIMALS
BODY
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
KIDNEYS
LOCAL IRRADIATION
MAMMALS
MEDICINE
MICE
NEPHRECTOMY
ORGANS
RADIATIONS
RADIOSENSITIVITY
RODENTS
SURGERY
VERTEBRATES
X RADIATION