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ACCELERATED INDUCTION OF NEOPLASMS IN MOUSE KIDNEYS X-IRRADIATED (690 r) WHILE UNDERGOING COMPENSATORY HYPERPLASIA

Technical Report ·
OSTI ID:4829176
;
Groups of young adult (C57LxA)F/sub 1/ mice were subjected to several different treatments: 690 rad whole-body x-irradiation; unilateral nephrectomy and no irradiation; 690 rad irradiation followed by unilateral nephrectomy 1 hour later; unilateral nephrectomy followed by 690 rad irradiation 3 hours later; unilateral nephrectomy, 690 rad 3 hours later. The mice were examined 1 year later for kidney neoplasms. The group nephrectomized and irradiated 3 hours later showed a high incidence (5 out of 11) of kidney adenomas, as compared with none in the mice irradiated only, or nephrectomized only. In addition, a high incidence (6 out of 10) of tubular or capsular renal proliferations was observed in the mice subjected to irradiation first and nephrectomy 1 hour later. These proliferations are considered to be early stages in the evaluation of the frank renal adenoma. Since the accelerated induction of kidney neoplasms observed, occurred under conditions which inhibit mitotic activity and compensatory hypertrophy in the mouse kidney, it was proposed that the development of these renal neoplasms was the consequence of a prolonged imbalance between the stimulus to mitosis or regeneration on the one hand, and the capacity for mitosis or regeneration, on the other. (auth)
Research Organization:
Naval Radiological Defense Lab., San Francisco
NSA Number:
NSA-16-004033
OSTI ID:
4829176
Report Number(s):
USNRDL-TR-532
Country of Publication:
Country unknown/Code not available
Language:
English

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Related Subjects

BIOLOGY AND MEDICINE
CARCINOGENESIS
KIDNEYS
MICE
MITOSIS
RADIATION DOSES
REGENERATION
SURGERY
TUMORS
X RADIATION