ACCELERATED INDUCTION OF NEOPLASMS IN MOUSE KIDNEYS X-IRRADIATED (690 RAD) WHILE UNDERGOING COMPENSATORY HYPERPLASIA

Technical Report · Wed Oct 11 04:00:00 EDT 1961

OSTI ID:4807746

Rosen, V J; Cole, L J

Groups of young adult (C57LXA)F/sub 1/ mice were subjected to different treatments including 690 rad whole-body x irradiation, unilateral nephrectomy and no irradiation, 690 rad irradiation followed by unilateral nephrectomy l hour later, unilateral nephrectomy followed by 690 rad irradiation 3 hours later, and unilateral nephrectomy, 690 rad 3 hours later. The mice were examined 1 year or 18 months later for kidney neoplasms. The group nephrectomized and irradiated 3 hours later showed a high incidence (l0 out of 19) of kidney adenomas, as compared with none in the mice irradiated only, or nephrectomized only. A high incidence (ll out of l5) of tubular and Bowman's capsule proliferations was observed in the mice subjected to irradiation first. and nephrectomy l hour later. These proliferations are considered to be early stages in the evolution of the frank renal adenoma. Since the accelerated induction of kidney neoplasms observed, occurred under conditions which inhibit mitotic activity and compensatory hynertrophy in the mouse kidney, it is proposed that the development of these renal neoplasms is the consequence of a prolonged imbalance between the stimulus to hyperplasia on the one hand, and the capacity for hyperplasia in radiation-altered kidney cells on the other. (auth)

• Research Organization: Naval Radiological Defense Lab., San Francisco
• NSA Number: NSA-16-011465
• OSTI ID: 4807746
• Report Number(s): USNRDL-TR-532(Rev.)
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
CARCINOGENESIS
KIDNEYS
MICE
MITOSIS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
SURGERY
TUMORS
WEIGHT
X RADIATION