RADIOSENSITIVITY OF MOUSE KIDNEY UNDERGOING COMPENSATORY HYPERTROPHY

Technical Report · Fri Apr 01 04:00:00 EST 1960

OSTI ID:4169574

Rosen, V J; Cole, L J

Groups of 10-week old female LAF/sub 1/ mice were subjected to unilateral nephrectomy, and then to a single, high sublethal dose of x radiation (690 r) at 3 hours, or at 48 hours post-nephrectomy. The remaining right kidneys were removed 3 weeks after surgery, weighed and the weights compared with those of the left kidneys removed during nephrectomy. In mice irradiated 48 hours after nephrectomy, the capacity of the kidney to undergo compensatory hypertrophy was essentially the same as that of non-irradiated controls, attaining as much as 50% increase in weight by 3 weeks. By contrast, there was a marked inhibition of compensatory hypertrophy when the irradiation was carried out 3 hours after nephrectomy. When irradiation (690 r) was given one hour before unilateral nephrec tomy, there was no apparent impairment of the capacity of the kidney to undergo compensatory hypentrophy. Radiation-inhibition of compensatory hypentrophy was also shown to be correlated with suppression of mitotic activity in the kidneys as detected histologically 48 hours po st-nephrectomy. (auth)

• Research Organization: Naval Radiological Defense Lab., San Francisco
• NSA Number: NSA-14-014663
• OSTI ID: 4169574
• Report Number(s): USNRDL-TR-415
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
ANIMAL CELLS
BIOLOGY AND MEDICINE
KIDNEYS
MICE
MITOSIS
RADIATION DOSES
RADIATION EFFECTS
RADIOSENSITIVITY
SEX
SURGERY
WEIGHT
X RADIATION