RENAL HYPERTROPHY AND FUNCTION IN IRRADIATED AND NEPHRECTOMIZED RATS FED A HIGH PROTEIN DIET
Male rats exposed to a total of 740 rads of x radiation, were subsequently fed a hyperprotein diet and unilateraly nephrectomized to investigate functional and compensatory regenerative capacity of the kidney as probablel indices of residual radiation injury. The extent of compensatory hypertrophy after nephrectomy showed a significantly greater increase due to the hyperprotein diet but no effect by irradiation. Estimates of maximal tubular excretions of PAH, however, were significantly greater in the irradiated groups than in control groups when determined 3 weeks post-nephrectomy. Renal clearances of C/sub IN/ and C/sub PAH/ were significantly depressed after nephrectomy but not after radiation. Histological studies of the kidneys did not indicate renal damage by radiation except for an isolated instance of a renal neoplasm in an irradiated, nephrectomized rat fed a hypertension diet. The results indicate that radiation does not modify compensatory hypertrophy after unilateral nephrectomy but appears to increase the apparent functional capacity of the tubules. (auth)
- Research Organization:
- Naval Radiological Defense Lab., San Francisco
- NSA Number:
- NSA-15-023292
- OSTI ID:
- 4058478
- Report Number(s):
- USNRDL-TR-517
- Resource Relation:
- Other Information: Orig. Receipt Date: 31-DEC-61
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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