RENAL HYPERTROPHY AND FUNCTION IN IRRADIATED AND NEPHERECTOMIZED RATS FED A HIGH PROTEIN DIET

Journal Article · Mon Jan 01 04:00:00 EST 1962 · American Journal of Physiology (U.S.)

OSTI ID:4801187

Konishi, F; Brauer, R W

Male rats exposed to a total of 740 rad x irradiation were fed a high protein diet and unilaterally nephrectomized to investigate functional and compensatory regenerative capacity of the kidney as probable indices of residual radiation injury. The extent of compensatory hypertrophy after nephrectomy showed a significantly greater increase due to the high protein diet but no effect due to irradiation. Estimates of maximal tubular excretions of p- aminohippurate (PAH), however, were significantly greater in irradiated groups than in cortrol groups when determthed 3 weeks postnephrectomy. Renal clearances of C/sub In/ and C/sub PHA/ were slgnlficantly depressed after nephreetomy but not after radiation. Histoiogical studies of the kidneys did not indicate renal damage by radiation except for an isolated instance of a renal neoplasm in an irradiated, mephrectomized rat fed a high protein diet. The results indicate that radiation does not modify compensatory hypertrophy after unilateral nephrectomy but appears to increase the apparent functional capacity of the tubules. (auth)

• Research Organization: U.S. Naval Radiological Defense Lab., San Francisco
• NSA Number: NSA-16-008555
• OSTI ID: 4801187
• Journal Information: American Journal of Physiology (U.S.), Journal Name: American Journal of Physiology (U.S.) Vol. Vol: 202; ISSN AJPHA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BODY
DIET
KIDNEYS
PHYSIOLOGY
PROTEINS
QUANTITY RATIO
RADIATION DOSES
RATS
REGENERATION
SURGERY
TUMORS
URINE
X RADIATION