THE EFFECT OF HIGH PROTEIN DIETS ON RENAL HYPERTROPHY IN RATS FOLLOWING WHOLE-BODY IRRADIATION

Technical Report · Thu May 18 04:00:00 EDT 1961

OSTI ID:4041495

Konishi, F; Rosen, V J; Brauer, R W

The relationship between high protein intake and increase in kidney weight was investigated in rats exposed to a single dose of 375 rad of x radiation. Attempts were made to characterize the degree of renal hypertrophy and hyperplasia involved by employing irradiation as an inhibitor of cellular proliferation. Rats were fed a high protein diet and exposed to radiation at various points of the feeding regime. The high protein diet significantly increased kidney weight in all cases but the increase was not influenced by the dose employed, or time of administration. However, histological studies of the kidneys showed that irradiation reduced the incidences of abnormal tubular hpperplasia. The renal lesions also appeared much earlier than previously reported by other investigators. Rats fed high protein diets appeared to recover body weight loss from the irradiation at a faster rate than those fed a basal diet. A possfble mechanism is briefly discussed. (auth)

• Research Organization: Naval Radiological Defense Lab., San Francisco
• NSA Number: NSA-15-023290
• OSTI ID: 4041495
• Report Number(s): USNRDL-TR-510
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BODY
DIET
IRRADIATION
KIDNEYS
PROTEINS
QUANTITY RATIO
RADIATION DOSES
RADIATION INJURIES
RADIATION PROTECTION
RATS
RECOVERY
WHOLE-BODY IRRADIATION