THE EFFECT OF HIGH-PROTEIN DIETS ON RENAL HYPERTROPHY IN RATS AFTER WHOLE- BODY IRRADIATION

Journal Article · Fri Dec 01 04:00:00 EST 1961 · Radiation Research

DOI:https://doi.org/10.2307/3571119· OSTI ID:4822206

Konishi, F; Rosen, V J; Brauer, R W

The relationship between high-protein intake and increase in kidney weight was investigated in rats exposed to a single dose of 375 rads of x radiation. Attempts were made to characterize the degree of renal hypertrophy and hyperplasia involved by employing radiation as an inhibitor of cellular proliferation. Rats were fed a high-protein diet and exposed to radiation at various points of the feeding regime. The high-protein diet significantly increased kidney weight in all cases, but the increase was not influenced by the x ray dose employed or the time of administration. However, histological studies of the kidneys showed that radiation reduced the incidences of abnormal tubular hyperplasia. The renal lesions also appeared much earlier than previously reported by other investigators. Rats fed high-protein diets appeared to recover from the radiation-induced loss in body weight at a faster rate than those fed a basal diet. A possible mechanism is briefly discussed. (auth)

• Research Organization: Naval Radiological Defense Lab., San Francisco
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-005211
• OSTI ID: 4822206
• Journal Information: Radiation Research, Journal Name: Radiation Research Vol. Vol: 15
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
DIET
KIDNEYS
PROTEINS
QUANTITY RATIO
RADIATION DOSES
RATS
RECOVERY
WEIGHT
X RADIATION