ACCELERATED INDUCTION OF KIDNEY NEOPLASMS IN MICE AFTER X RADIATION (690 Rad) AND UNILATERAL NEPHRECTOMY

Journal Article · Tue May 01 04:00:00 EDT 1962 · Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst.

OSTI ID:4830802

Rosen, Jr, V J; Cole, L J

Groups of young adult (C57L x A)F/sub 1/ mice were subjected to several dlfferent treatments includlng 690 rad wholebody x radiation, unilateral nephrectomy and no irradiatlon, 690 rad followed by unilateral nephrectomy l hour later, unilateral nephrectomy followed by 690 rad 3 hours later, and unllateral nephrectomy followed by 690 rad 48 hours later. The mlce were examlned l year or l8 months later for kidney neoplasms. The group nephrectomized and irradiated 3 hours later showed a high lncldence (lO out of l9) of kldney adenomas, as compared with none ln the mlce irradiated only, or nephrectomlzed only. In addltion, a high incldence (11 out of 15) of tubular and Bowman's capsule proliferations was observed in the mlce subjected to irradiation first and nephrectomy 1 hour later. These proliferatlons are considered to be early stages ln the development of the frank renal adenoma. The findings suggest that the occurrence of renal neoplasms ln these x-irradiated mice was greatiy increased as a consequence of the interaction of the speciflc prollferative stlmulus (unllateral nephrectomy) on radiation-altered kidney cells. (auth)

• Research Organization: Naval Radiological Defense Lab., San Francisco
• NSA Number: NSA-16-018778
• OSTI ID: 4830802
• Journal Information: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst., Journal Name: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst. Vol. Vol: 28; ISSN JNCIA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ADENOMAS
ANIMAL CELLS
BIOLOGY AND MEDICINE
CARCINOGENESIS
KIDNEYS
MICE
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
SURGERY
TUMORS
X RADIATION