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Effects of dose and of partial body ionizing radiation on taste aversion learning in rats with lesions of the area postrema

Journal Article · · Physiol. Behav.; (United States)
; ;
The effect of area postrema lesions on the acquisition of a conditioned taste aversion following partial body exposure to ionizing radiation was investigated in rats exposed to head-only irradiation at 100, 200 and 300 rad or to body-only irradiation at 100 and 200 rad. Following head-only irradiation area postrema lesions produced a significant attenuation of the radiation-induced taste aversion at all dose levels, although the rats still showed a significant reduction in sucrose preference. Following body-only exposure, area postrema lesions completely disrupted the acquisition of the conditioned taste aversion. The results are interpreted as indicating that: (a) the acquisition of a conditioned taste aversion following body-only exposure is mediated by the area postrema; and (b) taste aversion learning following radiation exposure to the head-only is mediated by both the area postrema and a mechanism which is independent of the area postrema.
Research Organization:
Behavioral Sciences Department, Armed Forces Radiobiology Research Institute, Bethesda, MD
OSTI ID:
6722917
Journal Information:
Physiol. Behav.; (United States), Journal Name: Physiol. Behav.; (United States) Vol. 32:1; ISSN PHBHA
Country of Publication:
United States
Language:
English

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Related Subjects

550100 -- Behavioral Biology
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DOSE-RESPONSE RELATIONSHIPS
IONIZING RADIATIONS
LEARNING
MAMMALS
NERVOUS SYSTEM
ORGANS
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
SENSE ORGANS
TASTE BUDS
VERTEBRATES