Effects of dose and of partial body ionizing radiation on taste aversion learning in rats with lesions of the area postrema
- Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
The effect of area postrema lesions on the acquisition of a conditioned taste aversion following partial body exposure to ionizing radiation was investigated in rats exposed to head-only irradiation at 100, 200 and 300 rad or to body-only irradiation at 100 and 200 rad. Following head-only irradiation area postrema lesions produced a significant attenuation of the radiation-induced taste aversion at all dose levels, although the rats still showed a significant reduction in sucrose preference. Following body-only exposure, area postrema lesions completely disrupted the acquisition of the conditioned taste aversion. The results are interpreted as indicating that: (a) the acquisition of a conditioned taste aversion following body-only exposure is mediated by the area postrema; and (b) taste aversion learning following radiation exposure to the head-only is mediated by both the area postrema and a mechanism which is independent of the area postrema.
- OSTI ID:
- 6537022
- Journal Information:
- Physiol. Behav.; (United States), Vol. 32:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LEARNING
BIOLOGICAL RADIATION EFFECTS
AVOIDANCE
BRAIN
CONDITIONED REFLEXES
DOSE-RESPONSE RELATIONSHIPS
GAMMA RADIATION
PARTIAL BODY IRRADIATION
RATS
SACCHAROSE
SURGERY
ANIMALS
BEHAVIOR
BIOLOGICAL EFFECTS
BODY
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
DISACCHARIDES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MEDICINE
NERVOUS SYSTEM
OLIGOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
REFLEXES
RODENTS
SACCHARIDES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals