Effects of dose and of partial body ionizing radiation on taste aversion learning in rats with lesions of the area postrema

Journal Article · Sun Jan 01 04:00:00 EST 1984 · Physiol. Behav.; (United States)

DOI:https://doi.org/10.1016/0031-9384(84)90081-7· OSTI ID:6537022

Rabin, B M; Hunt, W A; Lee, J ^[1]

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1. Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)

The effect of area postrema lesions on the acquisition of a conditioned taste aversion following partial body exposure to ionizing radiation was investigated in rats exposed to head-only irradiation at 100, 200 and 300 rad or to body-only irradiation at 100 and 200 rad. Following head-only irradiation area postrema lesions produced a significant attenuation of the radiation-induced taste aversion at all dose levels, although the rats still showed a significant reduction in sucrose preference. Following body-only exposure, area postrema lesions completely disrupted the acquisition of the conditioned taste aversion. The results are interpreted as indicating that: (a) the acquisition of a conditioned taste aversion following body-only exposure is mediated by the area postrema; and (b) taste aversion learning following radiation exposure to the head-only is mediated by both the area postrema and a mechanism which is independent of the area postrema.

• OSTI ID: 6537022
• Journal Information: Physiol. Behav.; (United States), Journal Name: Physiol. Behav.; (United States) Vol. 32:1; ISSN PHBHA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AVOIDANCE
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
CONDITIONED REFLEXES
DISACCHARIDES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GAMMA RADIATION
IONIZING RADIATIONS
IRRADIATION
LEARNING
MAMMALS
MEDICINE
NERVOUS SYSTEM
OLIGOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
PARTIAL BODY IRRADIATION
RADIATION EFFECTS
RADIATIONS
RATS
REFLEXES
RODENTS
SACCHARIDES
SACCHAROSE
SURGERY
VERTEBRATES