Distribution and pathological effects of Pu in juvenile beagles

Journal Article · Sat Nov 01 04:00:00 EST 1980 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575303· OSTI ID:6710300

Bruenger, F W ^[1]; Stevens, W; Stover, B J; Taylor, G N; Smith, J M; Buster, D S; Atherton, D R

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1. Univ. of Utah, Salt Lake City

Twelve juvenile beagles 90 days old were injected intravenously with 2.8 ..mu..Ci /sup 239/Pu/kg. All attained normal skeletal size and normal weight. However, all died from osteosarcoma with an average survival time of 1306 +- 163 days after injection. At death the liver contained 12.7 +- 2% of the injected /sup 239/Pu, and less than 1% was in the total of kidneys, lung, and spleen. In a liver homogenate, free of nuclei and debris, most of the Pu was bound to ferritin in the cytosol or found with microsomes. No overt evidence of radiation-induced liver damage was discernible. At death, the juvenile skeletons contained 56.0 +- 3.1% compared to 44% in beagles injected as young adults. Highly active bone growth and turnover produced a skeletal redistribution pattern of Pu which differed from that observed in young adults. The cumulative average dose to the anatomical skeleton was 2850 +- 443 rad. Seventeen bone tumors were produced, located predominantly in areas with high concentrations of Pu and rapid bone turnover rates. Skeletal radiographs taken at death revealed 33 fractures, all of which had healed.

• DOE Contract Number: EY-76-C-02-0119
• OSTI ID: 6710300
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 84:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ALPHA PARTICLES
ANIMALS
BEAGLES
BIOLOGICAL HOT SPOTS
BIOMEDICAL RADIOGRAPHY
BODY
BONE FRACTURES
CELL CONSTITUENTS
CHARGED PARTICLES
COMPLEXES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DOGS
EVEN-ODD NUCLEI
FERRITIN
GLANDS
HEAVY NUCLEI
INJURIES
IRON COMPLEXES
ISOTOPES
JUVENILES
LIVER
LYSOSOMES
MAMMALS
MEDICINE
MICROSOMES
MITOCHONDRIA
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
OSTEOSARCOMAS
PATHOLOGICAL CHANGES
PLUTONIUM 239
PLUTONIUM ISOTOPES
PROTEINS
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RETENTION
SARCOMAS
SKELETAL DISEASES
SKELETON
TISSUE DISTRIBUTION
TRANSITION ELEMENT COMPLEXES
VERTEBRATES
YEARS LIVING RADIOISOTOPES