Plutonium retention, excretion, and distribution in juvenile beagles soon after injection

Journal Article · Fri Sep 01 04:00:00 EDT 1978 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574849· OSTI ID:6858246

Lloyd, R D; McFarland, S S; Atherton, D R; Mays, C W

Six beagles, aged 3 months, were injected intravenously with 0.4 ..mu..Ci of /sup 239/Pu + 0.4 ..mu..Ci of /sup 237/Pu as the citrate complex. Retention in liver and in nonliver tissue (mainly skeleton) was measured serially in the living dogs by a combination of total- and partial-body counting, utilizing the 60- and 100-keV photons from /sup 237/Pu. About 11% of the injected Pu was excreted in the first 21 days with about 5% in urine and 6% in feces. One animal was sacrificed at 7 days, another at 14 days, and the remaining dogs at 28, 56, 89, and 119 days after injection for distribution studies. Early retention of Pu in liver was lower in juveniles (11 to 15%) than observed previously in adults aged 17 months (31 to 37%), while early skeletal retention was greater for juveniles (62 to 75%) than for adults (50 to 60%). Plutonium content of most other tissues was similar in adults and juveniles. The distribution of skeletal Pu was significantly greater for juveniles in the paws and lower leg bones by factors of 2 to 5, but greater for adults by about a factor of 2 in the thoracic and lumbar vertebrae and in the rib cage.

• Research Organization: Univ. of Utah, Salt Lake City
• OSTI ID: 6858246
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Journal Issue: 3 Vol. 75:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPLEXES
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
AGE DEPENDENCE
ALPHA DECAY RADIOISOTOPES
ANIMALS
BEAGLES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CARBOXYLIC ACID SALTS
CITRATES
CLEARANCE
COMPARATIVE EVALUATIONS
COMPLEXES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DOGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXCRETION
FECES
GLANDS
HEAVY NUCLEI
INJECTION
INTAKE
INTERNAL CONVERSION RADIOISOTOPES
INTRAVENOUS INJECTION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
JUVENILES
LIVER
MAMMALS
NUCLEI
ORGANS
PLUTONIUM 237
PLUTONIUM 239
PLUTONIUM COMPLEXES
PLUTONIUM ISOTOPES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RETENTION
SECONDS LIVING RADIOISOTOPES
SKELETON
TISSUE DISTRIBUTION
TRANSURANIUM COMPLEXES
URINE
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES