Radium rentention and dosimetry in juvenile beagles
Retention of administered /sup 226/Ra was substantially greater in beagles injected as 3-month-old juveniles than as 1.4-year-old adults, but the measured /sup 222/Rn//sup 226/Ra ratio in bone was significantly less in juveniles for about the first 600 days after injection. An equation that describes the total-body biological retention R in beagles injected with /sup 226/Ra at 3 months of age at any time t (in days) after injection during the first 6.6 years is R = 0.331e/sup -0.206t/ + 0.245e/sup -0.00374t/ + 0.424e/sup -0.000114t/. The rate constant of the final term in the equation for juveniles is similar to that for young adults, suggesting that this component reflects the net turnover rate in the slowly remodeling component of adult bone. Compared to young adult beagles, animals injected as juveniles had a greater fraction of their retained /sup 226/Ra in parts of the skeleton containing much cortical bone, such as paws, and a smaller fraction in those parts containing much trabecular bone.
- Research Organization:
- Univ. of Utah, Salt Lake City
- DOE Contract Number:
- AC02-76EV00119
- OSTI ID:
- 5741215
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 94:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADULTS
AGE GROUPS
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMALS
BEAGLES
BODY
CLEARANCE
DATA
DAYS LIVING RADIOISOTOPES
DOGS
DOSIMETRY
EVEN-EVEN NUCLEI
EXCRETION
EXPERIMENTAL DATA
HEAVY NUCLEI
INFORMATION
ISOTOPE RATIO
ISOTOPES
JUVENILES
MAMMALS
NUCLEI
NUMERICAL DATA
ORGANS
RADIOISOTOPES
RADIUM 226
RADIUM ISOTOPES
RADON 222
RADON ISOTOPES
RETENTION
SKELETON
VERTEBRATES
YEARS LIVING RADIOISOTOPES