Age and dosage-level dependence of radium retention in beagles
Radium retention was measured over the lifespan of 46 beagles exposed by eight semimonthly injections at 60 to 160, 120 to 220, or 435 to 535 days of age. Injection dosage levels ranged from 0.37 to 10 ..mu..Ci of /sup 226/Ra/kg. The fractional retention of each animal is described in terms of a modified power function, R = ((t + d)/d)/sup -//sup b/. Young adult beagles (approximately equal to 10 kg) injected at a mean age (A) of 485 days with /sup 226/Ra at dosage levels of 10, 3.3, 1.11, and 0.37 ..mu..Ci/kg had mean values for d and b of (0.897; 0.187), (2.015; 0.206), (2.778; 0.257), and (3.894; 0.274), respectively. Juvenile beagles injected with 10 ..mu..Ci/kg at A = 110 days (average weight approximately equal to 6 kg) and at A = 170 days (average weight approximately equal to 10 kg) had mean values for d and b of (137; 0.277) and (5.53; 0.086), respectively. The d values are geometric means and the units are days; b values are arithmetic means. The formula for deriving the age-dependent retention function for dogs is given. The beagle results were correlated with human data in terms of age-to-equivalent fraction of adult body calcium content and were used to construct a similar age-dependent retention function for chronically exposed people. The correlation of age-dependent retention functions for beagles and humans is used to estimate scaling factors between the two species for the fraction of injected dosage associated with bone for various ages of exposure.
- Research Organization:
- Univ. of California, Davis
- OSTI ID:
- 6858263
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 75:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADULTS
AGE DEPENDENCE
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMALS
BEAGLES
CHRONIC EXPOSURE
DOGS
DOSE-RESPONSE RELATIONSHIPS
EVEN-EVEN NUCLEI
HEAVY NUCLEI
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPES
JUVENILES
MAMMALS
NUCLEI
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIUM 226
RADIUM ISOTOPES
RETENTION FUNCTIONS
VERTEBRATES
YEARS LIVING RADIOISOTOPES